TAILIEUCHUNG - Synopsis of arachidonic acid metabolism: A review

Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and flexibility. The four double bonds of AA predispose it to oxygenation that leads to a plethora of metabolites of considerable importance for the proper function of the immune system, promotion of allergies and inflammation, resolving of inflammation, mood, and appetite. The present review presents an illustrated synopsis of AA metabolism, corroborating the instrumental importance of AA derivatives for health and well-being. It provides a comprehensive outline on AA metabolic pathways, enzymes and signaling cascades, in order to develop new perspectives in disease treatment and diagnosis. | Journal of Advanced Research 11 2018 23-32 Contents lists available at ScienceDirect Journal of Advanced Research journal homepage locate jare Review Synopsis of arachidonic acid metabolism A review Violette Said Hanna Ebtisam Abdel Aziz Hafez Chemistry Department Faculty of Science Cairo University Giza 12613 Egypt Check for updates GRAPHICAL ABSTRACT Sites of hydrolysis for each phospholipase PLA1 PLA2 PLC and PLD . ARTICLE INFO ABSTRACT Article history Received 10 January 2018 Revised 8 March 2018 Accepted 11 March 2018 Available online 13 March 2018 Keywords Arachidonic acid Delta desaturases Lipo- and cyclo-oxygenases Eicosanoids Endocannabinoids Isoprostanes Arachidonic acid AA a 20 carbon chain polyunsaturated fatty acid with 4 double bonds is an integral constituent of biological cell membrane conferring it with fluidity and flexibility. The four double bonds of AA predispose it to oxygenation that leads to a plethora of metabolites of considerable importance for the proper function of the immune system promotion of allergies and inflammation resolving of inflammation mood and appetite. The present review presents an illustrated synopsis of AA metabolism corroborating the instrumental importance of AA derivatives for health and well-being. It provides a comprehensive outline on AA metabolic pathways enzymes and signaling cascades in order to develop new perspectives in disease treatment and diagnosis. 2018 Production and hosting by Elsevier . on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license http licenses by-nc-nd . Introduction Arachidonic acid AA all-cis-5 8 11 14-eicosatetraenoic acid where eicos or eikosi in Greek refers to the number 20 is an omega-6 polyunsaturated fatty acid PUFA . Its chemical formula Peer review under responsibility of Cairo University. Corresponding author. E-mail address . Hanna . is C20H32O2 20 4 ro-6 where 20 4 .

• Hoá học
• Arachidonic acid
• Delta desaturases
• Lipo and cyclo oxygenases
• Synopsis of arachidonic acid metabolism
• Arachidonic acid metabolism
• Is arachidonic acid
• Arachidonic acid an endoschistosomicide
• Rat schistosomiasis
• Oil Red O staining
• Specific anti ARA antibody based
• Polyunsaturated fatty acids
• Sulfur amino acid
• Hydrogen sulfide
• Nitric oxide
• Metabolic engineering
• Potential source
• Plants as potential source
• BMC Biotechnology
• Mortierella Alpina
• Dissolved oxygen
• Heavy ion mutagenesis
• Octyl gallate
• Molecular breeding
• Fatty acid desaturase
• Mortierella alpina 1S 4
• Unsaturated fatty acids
• Free radicals
• Metabolites function
• Endogenous antimicrobial molecules
• Lipoxin A4
• Pre eclampsia
• Diabetes mellitus
• Hypertension and diabetes mellitus
• Ion channels
• Physiological roles
• Potential health benefits
• Membranes undergoes reacylation cycles
• BMC Cancer
• Cancer remains
• Prostaglandin E2
• Methodological limitations
• Type 2 cytokines
• Schistosomiasis vaccine
• Metabolic syndrome
• Pathogenic potential of uric acid
• BMC Geriatrics
• Lifestyle habits
• Long chain polyunsaturated fatty acids
• Cognitive leisure activities
• Maintaining cognitive function
• báo cáo khoa học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• Report medicine
• traditional medicine
• scientific reports
• medical knowledge
• medical research
• analysis of cytoplasmic
• Structural biochemistry
• oxidation
• bacteria
• chemical reaction
• Leptinotarsa decemlineata
• Treating fungus injected
• Eicosanoid biosynthesis
• B
• bassiana
• L
• decmlineata
• Schistosoma mansoni
• Antibody response
• Uric and arachidonic acid
• Papain enzymatic activity
• The protection induced
• Cysteine protease against
• Schistosoma haematobium
• Excretory–secretory products
• Type 2 adjuvants
• BMC Chemistry
• Dibenzylidene ketone derivatives
• Computational studies
• Human capsaicin receptor
• Journal of Chemistry
• Nitro compounds
• N carbamothioyl
• Soybean 15 LOX
• Nitrophenoxy chromenone derivative
• Arachidonic acid (AA)
• BMC Pediatrics
• Human milk provides
• Infant nutrition
• Multifunctional iron binding protein
• Adjusted arachidonic acid
• BMC Plant Biology
• Diacylglycerol acyltransferase
• Lipid droplet
• Lobosphaera incisa
• Genome Biology
• Ovarian carcinoma
• Tumor associated macrophages
• Tumor microenvironment
• Malignancy associated ascites
• Signaling network