TAILIEUCHUNG - Effect of experimental diabetes mellitus on plasma lactate dehydrogenase and glutamic oxaloacetic transaminase levels in rabbits

Hyperglycemia was induced in 20 male, white, New Zealand rabbits (2-3 kg) (Oryctolagus cuniculus huxley) by alloxan (100 mg/kg body weight, .) and maintained for 16 weeks without insulin treatment. Blood samples were taken from both diabetic and non-diabetic rabbits at the same time for measurement of plasma enzymes. | Turk J Biol 26 (2002) 151-154 © TÜB‹TAK Effect of Experimental Diabetes Mellitus on Plasma Lactate Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Rabbits* ‹smail ÇEL‹K, Eflref YE⁄‹N Yüzüncü Y›l University, Faculty of Science, Van - TURKEY Fehmi ODABAfiO⁄LU Atatürk University, Faculty of Pharmacology, Erzurum - TURKEY Received: Abstract: Hyperglycemia was induced in 20 male, white, New Zealand rabbits (2-3 kg) (Oryctolagus cuniculus huxley) by alloxan (100 mg/kg body weight, .) and maintained for 16 weeks without insulin treatment. Blood samples were taken from both diabetic and non-diabetic rabbits at the same time for measurement of plasma enzymes. Levels of glutamic oxalacetic transaminase (GOT) and lactate dehydrogenase (LDH) were determined after treatment. The levels of LDH and GOT were ± U/L and ± U/L in the control group respectively. These parameters were ± U/L and ± U/L in the diabetic group respectively. It was observed that LDH (p ) in the diabetic group. In conclusion, we agree that routine use of LDH measurement to monitor diabetic status may be useful, but the characteristic parameters of diabetes mellitus are better indicators. Key Words: Diabetes mellitus, LDH, GOT, Rabbit Tavflanlarda Deneysel Diyabetin Plazma Laktat Dehidrogenaz ve Glutamik Oksalasetik Transaminaz Enzim Düzeylerine Etkisi Özet: Bu çal›flmada, diabet 20 erkek, beyaz, Yeni Zelanda ›rk› tavflan (Oryctolagus cuniculus huxley) alloxan verilerek (100 mg/kg vucut .) oluflturuldu ve insulin tedavisi yap›lmaks›z›n 16 hafta bekletildi. Plazma enzimlerini ölçümü için kan örnekleri hem diabetik hemde kontrol grublar›ndan al›nd›. Muameleden sonra laktat dehidrogenaz (LDH) ve glutamik oksalasetik transaminaz (GOT) seviyeleri belirlendi. LDH ve GOT seviyeleri s›ras›yla, kontrol grubunda 155,6 ± 41,9 U/L ve 47,0 ± 20,4 U/L iken, diabetli grubunda 286,9 ± 142,9 U/L ve 93,9 ± 62,5 U/L idi. Yap›lan istatistiki .

• Sinh học
• Diabetes mellitus
• Glutamic oxalacetic transaminase
• Lactate dehydrogenase
• New Zealand rabbits
• Non diabetic rabbits
• Plasma enzymes
• Anti diabetes mellitus plants
• Active principles
• Sustainable utilization
• Anti diabetes mellitus phytochemicals
• Oral hypoglycemic agents
• Combination medicines
• Arachidonic acid
• Lipoxin A4
• Pre eclampsia
• Hypertension and diabetes mellitus
• Glycated hemoglobin
• Diagnosis and management
• Diabetes mellitus in dogs
• Diabetes in dogs
• BMC Cancer
• Breast cancer
• Female diabetes
• Type 2 diabetes mellitus
• Cox regression
• CNS Complications
• Complex Relationship
• Diabetic Nephropathy
• Ultrasound Placenta
• Casein Kinase 2 Alpha 1
• Real time quantitative polymerase chain reactions
• Enzyme linked immunosorbent
• Comparative risk of diabetes mellitus
• Diabetes mellitus in patients
• Rheumatoid arthritis treated
• Targeted synthetic disease modifying drugs
• Rheumatoid arthritis treated with biologic
• BMC Pediatrics
• Extract of Gingko biloba
• High fat diet
• Pancreatic β cells
• HRQOL and selfmanagement
• Lalitpur and Jhansi districts
• Diabetes mellitus subjects
• Demographic profile
• Knowledge of diabetes mellitus
• Residents of Tura town
• Prestructured questionnaire
• Data were collected
• Candida spp
• Candida albicans
• Candida species
• Diabetes mellitus patient
• Weight gain
• Thiazolidinediones in type 2
• TZDs exert weight gain
• Mechanism of TZDs on weight gain
• Diabetes mellitus patients
• Polycystic ovary syndrome
• Gestational diabetes mellitus
• Assisted reproductive technology
• Gestational diabetes mellitus in women
• BMC Musculoskeletal Disorders
• Type 1 diabetes mellitus
• Hyperglycaemia contributes
• Destroys insulin producing β cells
• Tapinanthus dodoneifolius
• Lipid profile
• Antioxidant potential
• Leaves of Tapinanthus dodoneifolius
• Lecture Diabetes mellitus
• Overview of diabetes
• Discussion about guidelines of diabetes management
• Implementation in clinical practice
• Increase in blood sugar
• Diabetes Control and Complications Trial
• Diabetes management
• Parent child interactional behaviors
• Healthcare resource utilization
• Hospital claims database analysis
• Raloxifene hydrochloride
• Retrospective cohort study
• Pregnancy outcomes
• Gestational diabetes
• Body mass index
• Oral glucose tolerance test
• Parent–child interaction
• Rating scale
• Prostate cancer diagnosis
• Gonadotropin releasing hormone agonists
• Prostate cancer
• BMC Geriatrics
• Myocardial infarction
• Type 2 diabetes
• Impaired fasting glucose
• Glucose tolerance
• C peptide
• Proliferative diabetic retinopathy
• Bariatric surgery