TAILIEUCHUNG - Lecture Principles of biochemistry - Chapter 12 (part 1): Citric acid cycle

Learning objectives of this chapter include: Know the overall reaction of the citric acid cycle, know the names of the intermediates of the TCA cycle from pyruvate to OAA, know the name of the enzymes involved in each step, know the co-factors involved in each step of the TCA cycle, know what co-factors are required by pyruvate dehydrogenase and beable to describe what their function is in the conversion of pyruvate to acetyl-CoA. | Chapter 12 (part 1) Citric Acid Cycle Gylcolysis TCA Cycle Electron Transport and Oxidative phosphorylation Entry into the TCA Cycle Pyruvate Dehydrogenase Citrate Synthase Only step in TCA cycle that involves the formation of a C-C bond Aconitase Isocitrate Dehydrogenase -Ketoglutarate Dehydrogenase Succinyl-CoA Synthetase Fumarase Malate Dehydrogenase Reduced Coenzymes Fuel ATP Production Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20 HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ Isocitrate Dehydrogenase 1 NADH= ATP a-ketoglutarate dehydrogenase 1 NADH= ATP Succinyl-CoA synthetase 1 GTP=1 ATP Sunccinate dehydrogenase 1 QH2= ATP Malate Dehydrogenase 1 NADH= ATP Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA Regulation of TCA Cycle Protein/amino acid Catabolites feed Into the TCA Cycle Fats breakdown and feed into the TCA Cycle TCA Cycle provides intermediates for many biosynthetic processes The Anaplerotic Reactions The "filling up" reactions PEP carboxylase - converts PEP to oxaloacetate Pyruvate carboxylase - converts pyruvate to oxaloacetate Malic enzyme converts pyruvate into malate Following the carbons through the TCA cycle

• Sinh học
• Principles of biochemistry
• Lecture Principles of biochemistry
• Nguyên lý hóa sinh
• Biochemical compounds
• Citric acid cycle
• TCA cycle
• Ebook Principles of biochemistry
• Principles of biochemistry (4th edition)
• The glyoxylate cycle
• Fatty acid catabolism
• Electron Transfer reactions
• Evolutionary foundations
• Protein interactions modulated
• Nucleic acid structure
• Biological systems
• Biological macromolecules
• Chemical principles
• Properties of water
• Hydrogen bonding
• Amino acids
• Amino acid structure
• Protein purification
• Cell extract
• Protein classification
• Protein 3 Dimensional structure
• Protein folding
• Protein 3 D structure
• 3 D structure
• Oxygen binding curve
• Enzyme kinetics
• Rate constants
• Catalytic Power
• Classes of enzymes
• Inhibitor kinetics
• Enzyme regulation
• Allosteric regulation
• Enzyme action
• Mechanisms of enzyme action
• Ions Cofactors
• Metal ion
• Biotin cofactor
• Conformation of monosaccharides
• Carbohydrate classifications
• Oligo carbohydrate
• Polysaccharides carbohydrate
• Lipid subclasses
• Acyl lipids
• Fluid mosaic model
• membrane transporters
• Metabolism proceed
• Anaeorbic process
• Triose Phosphate Isomerase
• Regulation of glycolysis
• Control points in glycolysis