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Learning objectives of this chapter include: Know the overall reaction of the citric acid cycle, know the names of the intermediates of the TCA cycle from pyruvate to OAA, know the name of the enzymes involved in each step, know the co-factors involved in each step of the TCA cycle, know what co-factors are required by pyruvate dehydrogenase and beable to describe what their function is in the conversion of pyruvate to acetyl-CoA. | Chapter 12 (part 1) Citric Acid Cycle Gylcolysis TCA Cycle Electron Transport and Oxidative phosphorylation Entry into the TCA Cycle Pyruvate Dehydrogenase Citrate Synthase Only step in TCA cycle that involves the formation of a C-C bond Aconitase Isocitrate Dehydrogenase -Ketoglutarate Dehydrogenase Succinyl-CoA Synthetase Fumarase Malate Dehydrogenase Reduced Coenzymes Fuel ATP Production Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20 HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ Isocitrate Dehydrogenase 1 NADH=2.5 ATP a-ketoglutarate dehydrogenase 1 NADH=2.5 ATP Succinyl-CoA synthetase 1 GTP=1 ATP Sunccinate dehydrogenase 1 QH2=1.5 ATP Malate Dehydrogenase 1 NADH=2.5 ATP Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA Regulation of TCA Cycle Protein/amino acid Catabolites feed Into the TCA Cycle Fats breakdown and feed into the TCA Cycle TCA Cycle provides intermediates for many biosynthetic processes The Anaplerotic Reactions The "filling up" reactions PEP carboxylase - converts PEP to oxaloacetate Pyruvate carboxylase - converts pyruvate to oxaloacetate Malic enzyme converts pyruvate into malate Following the carbons through the TCA cycle | Chapter 12 (part 1) Citric Acid Cycle Gylcolysis TCA Cycle Electron Transport and Oxidative phosphorylation Entry into the TCA Cycle Pyruvate Dehydrogenase Citrate Synthase Only step in TCA cycle that involves the formation of a C-C bond Aconitase Isocitrate Dehydrogenase -Ketoglutarate Dehydrogenase Succinyl-CoA Synthetase Fumarase Malate Dehydrogenase Reduced Coenzymes Fuel ATP Production Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20 HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ Isocitrate Dehydrogenase 1 NADH=2.5 ATP a-ketoglutarate dehydrogenase 1 NADH=2.5 ATP Succinyl-CoA synthetase 1 GTP=1 ATP Sunccinate dehydrogenase 1 QH2=1.5 ATP Malate Dehydrogenase 1 NADH=2.5 ATP Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA Regulation of TCA Cycle Protein/amino acid Catabolites feed Into the TCA Cycle Fats breakdown and feed into the TCA Cycle TCA Cycle provides intermediates for many biosynthetic processes The Anaplerotic Reactions The "filling up" reactions PEP carboxylase - converts | Chapter 12 (part 1) Citric Acid Cycle Gylcolysis TCA Cycle Electron Transport and Oxidative phosphorylation Entry into the TCA Cycle Pyruvate Dehydrogenase Citrate Synthase Only step in TCA cycle that involves the formation of a C-C bond Aconitase Isocitrate Dehydrogenase -Ketoglutarate Dehydrogenase Succinyl-CoA Synthetase Fumarase Malate Dehydrogenase Reduced Coenzymes Fuel ATP Production Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20 HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ Isocitrate Dehydrogenase 1 NADH=2.5 ATP a-ketoglutarate dehydrogenase 1 NADH=2.5 ATP Succinyl-CoA synthetase 1 GTP=1 ATP Sunccinate dehydrogenase 1 QH2=1.5 ATP Malate Dehydrogenase 1 NADH=2.5 ATP Total of 10 ATPs gained from oxidation of 1 Acetyl-CoA Regulation of TCA Cycle Protein/amino acid Catabolites feed Into the TCA Cycle Fats breakdown and feed into the TCA Cycle TCA Cycle provides intermediates for many biosynthetic processes The Anaplerotic Reactions The "filling up" reactions PEP carboxylase - converts PEP to oxaloacetate Pyruvate carboxylase - converts pyruvate to oxaloacetate Malic enzyme converts pyruvate into malate Following the carbons through the TCA .
