TAILIEUCHUNG - Lecture Principles of biochemistry - Chapter 4 (part 3): 3-D structure/Function

In this chapter you will learn: Structure of myoglobin and hemoglobin similar; understand oxygen binding curves (where high and low affinity binding occurs); understand positive cooperatively in relationship to oxygen binding to hemoglobin, be able to describe this in relationship to protein conformation and the sigmoidal oxygen binding curve; be able to describe T and R conformations of Hb; understand how oxygen binding changes Hb conformation; define allosteric interaction;. | Chapter 4 (part 3) 3-D Structure / Function Animal Scrapie: sheep TME (transmissible mink encephalopathy): mink CWD (chronic wasting disease): muledeer, elk BSE (bovine spongiform encephalopathy): cows Human CJD: Creutzfeld-Jacob Disease FFI: Fatal familial Insomnia Kuru PrPC PrPSc solubility soluble non soluble structure predominantly alpha-helical predominantly beta-sheeted multimerisation state monomeric multimeric (aggregates) infectivity non infectious infectious Susan W. Liebman, and James A. Mastrianni (2005) Trends in Molecular Medicine 11: 439-441 Myoglobin/ Hemoglobin First protein structures determined Oxygen carriers Hemoglobin transport O2 from lungs to tissues Myoglobin O2 storage protein Mb and Hb subunits structurally similar 8 alpha-helices Contain heme group Mb monomeric protein Hb heterotetramer (a2b2) myoglobin hemoglobin Heme group Heme = Fe++ bound to tertapyrrole ring (protoporphyrin IX complex) Heme non-covalently bound to globin proteins through His residue

• Sinh học
• Principles of biochemistry
• Lecture Principles of biochemistry
• Biological systems
• Biochemical compounds
• 3 D structure
• Oxygen binding curve
• Ebook Principles of biochemistry
• Principles of biochemistry (4th edition)
• The glyoxylate cycle
• Fatty acid catabolism
• Electron Transfer reactions
• Evolutionary foundations
• Protein interactions modulated
• Nucleic acid structure
• Biological macromolecules
• Chemical principles
• Properties of water
• Hydrogen bonding
• Amino acids
• Amino acid structure
• Protein purification
• Cell extract
• Protein classification
• Protein 3 Dimensional structure
• Protein folding
• Protein 3 D structure
• Enzyme kinetics
• Rate constants
• Catalytic Power
• Classes of enzymes
• Inhibitor kinetics
• Enzyme regulation
• Allosteric regulation
• Enzyme action
• Mechanisms of enzyme action
• Ions Cofactors
• Metal ion
• Nguyên lý hóa sinh
• Biotin cofactor
• Conformation of monosaccharides
• Carbohydrate classifications
• Oligo carbohydrate
• Polysaccharides carbohydrate
• Lipid subclasses
• Acyl lipids
• Fluid mosaic model
• membrane transporters
• Metabolism proceed
• Anaeorbic process
• Triose Phosphate Isomerase
• Regulation of glycolysis
• Control points in glycolysis
• Citric acid cycle
• TCA cycle