TAILIEUCHUNG - Lecture Biochemistry (2/e): Chapter 4 - Reginald Garrett, Charles Grisham

Lecture Biochemistry (2nd edition): Chapter 4 introduce Amino Acids. In this chapter students will be able to understand: Amino Acids: Building Blocks of proteins, Acid-Base chemistry of amino acids, reactions of Amino Acids, optical activity and stereochemistry of Amino Acids, spectroscopic properties of Amino Acids, separation and analysis of . Mixtures. | CHAPTER 4 Amino Acids to accompany Biochemistry, 2/e by Reginald Garrett and Charles Grisham All rights reserved. Requests for permission to make copies of any part of the work should be mailed to: Permissions Department, Harcourt Brace & Company, 6277 Sea Harbor Drive, Orlando, Florida 32887-6777 Outline : Amino Acids: Building Blocks of Proteins : Acid-Base Chemistry of Amino Acids : Reactions of Amino Acids : Optical Activity and Stereochemistry of Amino Acids : Spectroscopic Properties of Amino Acids : Separation and Analysis of . Mixtures Amino Acids Building Blocks of Proteins Amino Acids Can Join Via Peptide Bonds 20 Common Amino Acids You should know names, structures, pKa values, 3-letter and 1-letter codes Non-polar amino acids Polar, uncharged amino acids Acidic amino acids Basic amino acids Uncommon Amino Acids We'll see some of these in later chapters Hydroxylysine, hydroxyproline - collagen Carboxyglutamate - blood-clotting proteins Pyroglutamate - bacteriorhodopsin Phosphorylated amino acids - signaling device Acid-Base Chemistry Amino Acids are Weak Polyprotic Acids H2A+ + H2O HA0 + H3O+ Ka1 = [ HA0 ] [ H3O+ ] __ [H2A+ ] Acid-Base Chemistry The second dissociation (the amino group in the case of glycine): HA0 + H2O A¯ + H3O+ Ka2 = [ A¯ ] [ H3O+ ] __ [ HA0 ] pKa Values of the Amino Acids You should know these numbers and know what they mean! Alpha carboxyl group - pKa = 2 Alpha amino group - pKa = 9 These numbers are approximate, but entirely suitable for our purposes. pKa Values of the Amino Acids You should know these numbers and know what they mean Arginine, Arg, R: pKa(guanidino group) = Aspartic Acid, Asp, D: pKa = Cysteine, Cys, C: pKa = Glutamic Acid, Glu, E: pKa = Histidine, His, H: pKa = pKa Values of the Amino Acids You should know these numbers and know what they mean Lysine, Lys, K: pKa = Serine, Ser, S: pKa = 13 Threonine, Thr, T: pKa

• Sinh học
• Lecture Biochemistry
• Biological phenomena
• Living systems
• Structure of cells
• Acid Base chemistry
• Reactions of Amino Acids
• Principles of biochemistry
• Lecture Principles of biochemistry
• Biological systems
• Biochemical compounds
• Biological macromolecules
• Chemical principles
• Properties of water
• Hydrogen bonding
• Amino acids
• Amino acid structure
• Protein purification
• Cell extract
• Protein classification
• Protein 3 Dimensional structure
• Protein folding
• Protein 3 D structure
• 3 D structure
• Oxygen binding curve
• Enzyme kinetics
• Rate constants
• Catalytic Power
• Classes of enzymes
• Inhibitor kinetics
• Enzyme regulation
• Allosteric regulation
• Enzyme action
• Mechanisms of enzyme action
• Ions Cofactors
• Metal ion
• Nguyên lý hóa sinh
• Biotin cofactor
• Conformation of monosaccharides
• Carbohydrate classifications
• Oligo carbohydrate
• Polysaccharides carbohydrate
• Lipid subclasses
• Acyl lipids
• Fluid mosaic model
• membrane transporters
• Metabolism proceed
• Anaeorbic process
• Triose Phosphate Isomerase
• Regulation of glycolysis
• Control points in glycolysis
• Citric acid cycle
• TCA cycle
• Additional pathways
• Carbohydrate metabolism
• Electron transport
• Chemosmotic theory