TAILIEUCHUNG - Báo cáo khoa học: Pentose phosphates in nucleoside interconversion and catabolism

Ribose phosphates are either synthesized through the oxidative branch of the pentose phosphate pathway, or are supplied by nucleoside phosphorylas-es. The two main pentose phosphates, ribose-5-phosphate and ribose-1-phos-phate, are readily interconverted by the action of phosphopentomutase. Ribose-5-phosphate is the direct precursor of 5-phosphoribosyl-1-pyrophos-phate, for bothde novoand ‘salvage’ synthesis of nucleotides. | FEBS Journal REVIEW ARTICLE Pentose phosphates in nucleoside interconversion and catabolism Maria G. Tozzi1 Marcella Camici1 Laura Mascia1 Francesco Sgarrella2 and Piero L. Ipata1 1 Dipartimento di Biologia Laboratorio di Biochimica Pisa Italy 2 Dipartimento di Scienze delFarmaco Sassari Italy Keywords deoxyribose-1-phosphate deoxyribose-5-phosphate nucleoside interconversion nucleoside transport pentose phosphate catabolism purine nucleoside phosphorylase pyrimidine salvage ribose-1-phosphate ribose-5-phosphate uridine phosphorylase Correspondence P. L. Ipata Dipartimento di Biologia Laboratorio di Biochimica Via S. Zeno 51 56100 Pisa Italy Fax 050 2213170 Tel 050 2213169 E-mail ipata@ Received 27 October 2005 revised 23 January 2006 accepted 25 January 2006 doi Ribose phosphates are either synthesized through the oxidative branch of the pentose phosphate pathway or are supplied by nucleoside phosphorylases. The two main pentose phosphates ribose-5-phosphate and ribose-1-phos-phate are readily interconverted by the action of phosphopentomutase. Ribose-5-phosphate is the direct precursor of 5-phosphoribosyl-1-pyrophos-phate for both de novo and salvage synthesis of nucleotides. Phosphorolysis of deoxyribonucleosides is the main source of deoxyribose phosphates which are interconvertible through the action of phosphopentomutase. The pentose moiety of all nucleosides can serve as a carbon and energy source. During the past decade extensive advances have been made in elucidating the pathways by which the pentose phosphates arising from nucleoside phosphorolysis are either recycled without opening of their furanosidic ring or catabolized as a carbon and energy source. We review herein the experimental knowledge on the molecular mechanisms by which a ribose-1-phosphate produced by purine nucleoside phosphorylase acting catabolically is either anabolized for pyrimidine salvage and 5-fluoro-uracil activation with uridine .

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