TAILIEUCHUNG - Báo cáo khoa học về: INVITED LECTURES

The innate immune system has provided an excellent model for study-ing complex regulatory networks at the levels of signal transduction and transcription. Virus infection of mammalian cells triggers the coor-dinate activation of multiple signaling pathways leading to the activa-tion of specific sets of transcription factors that assemble on the interferon-b (IFN-b) gene enhancer to form an enhanceosome. | Abstracts 1A. Chromosome Structure Movements and Insulators INVITED LECTURES 1. Chromosome Architecture and Nuclear Dynamics 1A. Chromosome Structure Movements and Insulators IL1A-1 Gene regulatory mechanisms in innate immunity T. Maniatis Harvard University Department of Molecular and Cellular Biology Cambridge MA USA The innate immune system has provided an excellent model for studying complex regulatory networks at the levels of signal transduction and transcription. Virus infection of mammalian cells triggers the coordinate activation of multiple signaling pathways leading to the activation of specific sets of transcription factors that assemble on the interferon-P IFN-P gene enhancer to form an enhanceosome. The function of the enhanceosome is to recruit histone acetylases and chromatin remodeling complexes that displace a phased nucleosome blocking the IFN-P promoter. Expression of the IFN-P gene leads to the secretion of IFN-P which binds to IFN receptors thus activating the JAK STAT signaling pathway. This results in the tyrosine phosphorylation of the transcription factor STAT1 and the formation of the ISGF3 complex consisting of the transcription factors STAT1 STAT2 and IRF-9. STAT1 is further phosphorylated at serine 708 by the non-canonical IkB kinase IKK e which is required for the activation of a subset of antiviral genes. In the absence of Serine 708 phosphorylation a STAT1 complex is formed but is unable to bind to a subset of IFN-inducible promoters. DNA sequence comparisons have identified distinct consensus sequences for IKK e-dependent and independent promoters. These observations suggest that the phosphorylation of STAT1 by IKK e regulates the structure and or composition of the ISGF3 complex which in turn determines the specificity of DNA binding and the nature of the anti-viral response. The results of recent studies bearing on the mechanisms of both IFN gene expression and the expression of IFN-inducible genes will be presented. IL1A-2 .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• medicine
• cell proliferation
• oxidation
• medical knowledge
• medical research
• analysis of cytoplasmic
• Crystal structure
• bacteria
• hemoglobin
• breast cancer
• chemical reaction
• gastric cancer
• hormone medicine
• tumor cells
• biochemical studies
• environmental medicine