TAILIEUCHUNG - Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

Solid tumours are complex structures in which the interdependent relation-ship between tumour and endothelial cells modulates tumour development and metastasis dissemination. The tumour microenvironment plays an important role in this cell interplay, and changes in its features have a major impact on tumour growth as well as on anticancer therapy respon-siveness. | IFEBS Journal REVIEW ARTICLE Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours S. Toffoli and C. Michiels Laboratory of Biochemistry and Cellular Biology URBC University of Namur - FUNDP Belgium Keywords apoptosis cancer chemoresistance endothelial cell hypoxia-inducible factor-1 intermittent hypoxia radioresistance reactive oxygen species reoxygenation tumor cell Correspondence C. Michiels Laboratory of Biochemistry and Cellular Biology URBC University of Namur - FUNDP 61 rue de Bruxelles 5000 Namur Belgium Fax 32 81 72 41 35 Tel 32 81 72 41 31 E-mail Received 1 March 2008 accepted 9 April 2008 Solid tumours are complex structures in which the interdependent relationship between tumour and endothelial cells modulates tumour development and metastasis dissemination. The tumour microenvironment plays an important role in this cell interplay and changes in its features have a major impact on tumour growth as well as on anticancer therapy responsiveness. Different studies have shown irregular blood flow in tumours which is responsible for hypoxia and reoxygenation phases also called intermittent hypoxia. Intermittent hypoxia induces transient changes the impact of which has been underestimated for a long time. Recent in vitro and in vivo studies have shown that intermittent hypoxia could positively modulate tumour development inducing tumour growth angiogenic processes chemoresistance and radioresistance. In this article we review the effects of intermittent hypoxia on tumour and endothelial cells as well as its impacts on tumour development. doi Introduction Hypoxia is increasingly perceived as one of the tumour microenvironment features favouring tumour cell survival and also resistance to chemotherapy and radiotherapy. Hypoxia is defined as a decrease in oxygen level within the tissue. However recent studies have shown that the time frame within which this .

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