TAILIEUCHUNG - Báo cáo khoa học: A novel four transmembrane spanning protein, CLP24 A hypoxically regulated cell junction protein

A novel hypoxically regulated intercellular junction protein (claudin-like protein of 24 kDa, CLP24) hasbeen identified that shows homology to the myelin protein 22/epithelial membrane protein 1/claudin family of cell junction proteins, which are involved in the modulation of paracellular per-meability. The CLP24 protein containsfour predicted transmembrane domains and a C-terminal protein–protein interaction domain. These domains are characteristic of the four transmembrane spanning (tetraspan) family of pro-teins, which includes myelin protein 22, and are involved in cell adhesion at tight, gap and adherens junctions | Eur. J. Biochem. 271 2584-2592 2004 FEBS 2004 doi A novel four transmembrane spanning protein CLP24 A hypoxically regulated cell junction protein Jonathan Kearsey Silvere Petit Catherine De Oliveira and Fabien Schweighoffer ExonHit Therapeutics Paris France A novel hypoxically regulated intercellular junction protein claudin-like protein of 24 kDa CLP24 has b e e n identified that shows homology to the myelin protein 22 epithelial membrane protein 1 claudin family of cell junction proteins which are involved in the modulation of paracellular permeability. The CLP24 protein contains four ỊTiei lieted transmembrane domains and a C-terminal protein-protein interaction domain. These domains are characteristic of the four transmembrane spanning tetraspan family of proteins which includes myelin protein 22 and are involved in cell adhesion at tight gap and adherens junctions. Expression profiling analyses show that CLP24 is highly expressed in lung heart kidney and placental tissues. Cellular studies confirm that the CLP24 protein localizes to cell-cell junctions add co-localiees with ehe b-catenin adherens junction-associated protein but not with tight junctions. Over-expression of CLP24 results in decreased adhesion between cells and functional paraohllular flux studies confirm that over-expression of the CLP24 protein modulates die juncdonal barrier I Lincdon. Thesd aata therefore suggest that CLP24 is a novel hypoxically regulated tetraspan adherens junction protein that modulates cell adhesion paracellular permeability and angiogenesis. Keywords adherens angiogenesis claudin DATAS hypoxia. Endothelial and epithelial cell sheetsline all the cavitiesof the body and are linked by specialized adhesive junctions that provide a selective barrier for the passage of plasma proteins circulating cells water and or solutes. Two types of adhesive junctions namely tight junctions and adherens junctions play a major role in controlling this .

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