TAILIEUCHUNG - Báo cáo khoa học: Expression and physiological role of CCN4⁄Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes

CCN4⁄Wnt-induced secreted protein 1 (WISP1) is one of the CCN (CTGF⁄Cyr61⁄Nov) family proteins. CCN members have typical structures composed of four conserved cysteine-rich modules and their variants lack-ing certain modules, generated by alternative splicing or gene mutations, have been described in various pathological conditions. | ỊFEBS Journal Expression and physiological role of CCN4 Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes Takeshi Yanagita1 2 Satoshi Kubota1 Harumi Kawaki1 Kazumi Kawata1 Seiji Kondo1 Teruko Takano-Yamamoto3 Shinji Tanaka4 and Masaharu Takigawa1 1 Department of Biochemistry Molecular Dentistry Okayama University Graduate Schoolof Medicine Dentistry and Pharmaceutical Sciences Japan 2 Department of Orthodontics and DentofacialOrthopedics Okayama University Graduate Schoolof Medicine Dentistry and Pharmaceutical Sciences Japan 3 Division of Orthodontics and DentofacialOrthopedics Tohoku University Graduate Schoolof Dentistry Miyagi Japan 4 Department of Hepato-Biliary-Pancreatic Surgery Graduate Schoolof Medicine and Dentistry Tokyo Medicaland DentalUniversity Japan Keywords cartilage CCN family chondrocyte differentiation splicing variant Wnt-induced secreted protein 1 WISP1 Correspondence M. Takigawa Department of Biochemistry and Molecular Dentistry Okayama University Graduate Schoolof Medicine Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho Okayama 700-8525 Japan Fax 81 86 235 6649 Tel 81 86 235 6645 E-mail takigawa@ Database The nucleotide sequence data described have been submitted to the GenBank database under the accession numbers EF025921 EF025922 and EF025923 Received 20 November 2006 revised 15 January 2007 accepted 19 January 2007 doi CCN4 Wnt-induced secreted protein 1 WISP1 is one of the CCN CTGF Cyr61 Nov family proteins. CCN members have typical structures composed of four conserved cysteine-rich modules and their variants lacking certain modules generated by alternative splicing or gene mutations have been described in various pathological conditions. Several previous reports described a CCN4 WISP1 variant WISP1v lacking the second module in a few malignancies but no information concerning the production of WISP1 variants in normal tissue is currently available. The .

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