TAILIEUCHUNG - Báo cáo khoa học: Nitric oxide in blood The nitrosative–oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease

There is growing evidence that altered production and⁄or spatio-temporal distribution of reactive oxidant species and reactive nitrosative species in blood creates oxidative and⁄or nitrosative stresses in the failing myo-cardium and endothelium. | FEBS Journal REVIEW ARTICLE Nitric oxide in blood The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease Maqsood M. Elahi1 Khalid M. Naseem2 and Bashir M. Matata1 1 The Cardiothoracic Centre LiverpoolNHS Trust UK 2 Centre for Atherothrombosis Research MedicalBiosciences University of Bradford UK Keywords cardiac E-C coupling cardiac hypertrophy hemoglobin oxidase NO signaling oxidases programmed cell death transduction pathways S-nitrosylation Correspondence B. M. Matata The Cardiothoracic Centre LiverpoolNHS Trust Thomas Drive LiverpoolL14 3PE UK Fax 44 151 293 2283 Tel 44 151 293 2293 E-mail matata_bashir@ Received 20 October 2006 revised 27 November 2006 accepted 19 December 2006 doi There is growing evidence that altered production and or spatio-temporal distribution of reactive oxidant species and reactive nitrosative species in blood creates oxidative and or nitrosative stresses in the failing myocardium and endothelium. This contributes to the abnormal cardiac and vascular phenotypes that characterize cardiovascular disease. These derangements at the system level can now be interpreted at the integrated cellular and molecular levels in terms of effects on signaling elements in the heart and vasculature. The end results of nitric oxide redox disequilibrium have implications for cardiac and vascular homeostasis and may result in the development of atherosclerosis myocardial tissue remodelling and hypertrophy. Reactive oxygen species reactive nitrogen species generation is also attributed to the transit from hypertrophic to apoptotic phenotypes a possible mechanism of myocardial failure. In this review we highlight the possible roles of altered production and or spatio-temporal distribution of reactive oxidant species and reactive nitrosative species in blood on the pathogenesis of the failing cardiovascular system. As the prototypical endothelium-derived relaxing factor .

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