TAILIEUCHUNG - Báo cáo khoa học: Revisiting the prediction of protein function at CASP6

The ability to predict the function of a protein, given its sequence and⁄or 3D structure, is an essential requirement for exploiting the wealth of data made available by genomics and structural genomics projects and is there-fore raising increasing interest in the computational biology community. | ềFEBS Journal Revisiting the prediction of protein function at CASP6 Marialuisa Pellegrini-Calace1 Simonetta Soro1 and Anna Tramontane1 2 1 Department of BiochemicalSciences A. Rossi Fanelli University La Sapienza Rome Italy 2 Istituto Pasteur Fondazione Cenci-Bolognetti University La Sapienza Rome Italy Keywords CriticalAssessment of Techniques for Protein Structure Prediction CASP function prediction protein function structural genomics Correspondence A. Tramontano Department of Biochemical Sciences A. Rossi Fanelli University La Sapienza Aldo Moro 5-00185 Rome Italy Fax 39 06 4440062 Tel 39 06 49910556 E-mail These authors contributed equally to this work. Received 21 February 2006 revised 11 April2006 accepted 5 May 2006 doi The ability to predict the function of a protein given its sequence and or 3D structure is an essential requirement for exploiting the wealth of data made available by genomics and structural genomics projects and is therefore raising increasing interest in the computational biology community. To foster developments in the area as well as to establish the state of the art of present methods a function prediction category was tentatively introduced in the 6th edition of the Critical Assessment of Techniques for Protein Structure Prediction CASP worldwide experiment. The assessment of the performance of the methods was made difficult by at least two factors a the experimentally determined function of the targets was not available at the time of assessment b the experiment is run blindly preventing verification of whether the convergence of different predictions towards the same functional annotation was due to the similarity of the methods or to a genuine signal detectable by different methodologies. In this work we collected information about the methods used by the various predictors and revisited the results of the experiment by verifying how often and in which cases a .

• Báo cáo khoa học
• Report medicine
• traditional medicine
• scientific reports
• medicine
• cell proliferation
• oxidation
• medical knowledge
• medical research
• analysis of cytoplasmic
• Crystal structure
• bacteria
• hemoglobin
• breast cancer
• chemical reaction
• gastric cancer
• hormone medicine
• tumor cells
• biochemical studies
• environmental medicine