TAILIEUCHUNG - Báo cáo khoa học: The C-type lectin-like domain superfamily

The superfamily of proteins containing C-type lectin-like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop (‘loop-in-a-loop’) stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. | ềFEBS Journal REVIEW ARTICLE The C-type lectin-like domain superfamily Alex N. Zelensky and Jill E. Gready ComputationalProteomics and Therapy Design Group John Curtin Schoolof MedicalResearch Australian National university Canberra Australia Subdivision Proteomics Keywords C-type lectin-like domain domain superfamily protein evolution carbohydrate binding Correspondence J. E. Gready ComputationalProteomics and Therapy Design Group Division of Molecular Bioscience John Curtin Schoolof MedicalResearch PO Box 334 Canberra ACT 2601 Australia Fax 61 2 6125 0415 Tel. 61 2 6125 8303 Website http dbmb gready Received 31 July 2005 revised 17 October 2005 accepted 24 October 2005 doi The superfamily of proteins containing C-type lectin-like domains CTLDs is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop loop-in-a-loop stabilized by two highly conserved disulfide bridges located at the bases of the loops as well as a set of conserved hydrophobic and polar interactions. The second loop called the long loop region is structurally and evolutio-narily flexible and is involved in Ca2 -dependent carbohydrate binding and interaction with other ligands. This loop is completely absent in a subset of CTLDs which we refer to as compact CTLDs these include the Link PTR domain and bacterial CTLDs. CTLD-containing proteins CTLDcps were originally classified into seven groups based on their overall domain structure. Analyses of the superfamily representation in several completely sequenced genomes have added 10 new groups to the classification and shown that it is applicable only to vertebrate CTLDcps despite the abundance of CTLDcps in the invertebrate genomes studied the domain architectures of these proteins do not match those of the vertebrate groups. Ca2 -dependent carbohydrate binding is the most common CTLD function in vertebrates and apparently

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