TAILIEUCHUNG - Báo cáo y học: " Presence of a functional but dispensable Nuclear Export Signal in the HTLV-2 Tax protein"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Presence of a functional but dispensable Nuclear Export Signal in the HTLV-2 Tax protein | Retrovirology BioMed Central Research Open Access Presence of a functional but dispensable Nuclear Export Signal in the HTLV-2 Tax protein Sébastien A Chevalier1 Laurent Meertens1 Sara Calattini1 Antoine Gessain1 Lars Kiemer2 and Renaud Mahieux 1 Address 1Unité d Epidémiologie et Physiopathologie des Virus Oncogènes Institut Pasteur Paris France and 2Center for Biological Sequence Analysis BioCentrum-DTU The Technical University of Denmark Building 208 DK-2800 Lyngby Denmark Email Sébastien A Chevalier - schevali@ Laurent Meertens - lmeerten@ Sara Calattini - scalatt@ Antoine Gessain - agessain@ Lars Kiemer - lars@ Renaud Mahieux - rmahieux@ Corresponding author Published 14 November 2005 Received 14 October 2005 Accepted 14 November 2005 Retrovirology 2005 2 70 doi 1742-4690-2-70 H This article is available from http content 2 1 70 2005 Chevalier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human T-cell leukemia virus type 1 and type 2 are related human retroviruses. HTLV-1 is the etiological agent of the Adult T-cell Leukemia Lymphoma and of the Tropical Spastic Paraparesis HTLV-1 Associated Myelopathy whereas HTLV-2 infection has not been formally associated with any T-cell malignancy. HTLV-1 and 2 genomes encode respectively the Tax1 and Tax2 proteins whose role is to transactivate the viral promoter. HTLV-1 and HTLV-2 Tax sequences display 28 divergence at the amino acid level. Tax1 is a shuttling protein that possesses both a non canonical nuclear import NLS and a nuclear export NES signal. We have recently demonstrated that Tax1 and Tax2 display different subcellular localization and that residues

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