TAILIEUCHUNG - Retrovirology Research BioMed Central Open Access Analysis of transcribed human endogenous

Retrovirology Research BioMed Central Open Access Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus env sequences Georg Laufer1, Jens Mayer2, Benedikt F Mueller1, Nikolaus Mueller-Lantzsch1 and Klemens Ruprecht*1,3 Address: 1Institute of Virology, Saarland University Hospital, Homburg, Germany, 2Department of Human Genetics, Saarland University Hospital, Homburg, Germany and 3Department of Neurology, Saarland University Hospital, Homburg, Germany Email: Georg Laufer - G_1982@; Jens Mayer - ; Benedikt F Mueller - ; Nikolaus Mueller-Lantzsch - vinmue@; Klemens Ruprecht* - * Corresponding author Published: 15 April 2009 Retrovirology 2009, 6:37 doi: Received: 14 January 2009 Accepted: 15 April 2009 This article is available from:. | Retrovirology BioMed Central Research Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus env sequences Georg Laufer1 Jens Mayer2 Benedikt F Mueller1 Nikolaus Mueller-Lantzsch1 and Klemens Ruprecht 1 3 Address 1Institute of Virology Saarland University Hospital Homburg Germany 2Department of Human Genetics Saarland University Hospital Homburg Germany and 3Department of Neurology Saarland University Hospital Homburg Germany Email Georg Laufer - G_1982@ Jens Mayer - Benedikt F Mueller - Nikolaus Mueller-Lantzsch - vinmue@ Klemens Ruprecht - Corresponding author Open Access Published 15 April 2009 Received 14 January 2009 Retrovirology 2009 6 37 doi 1742-4690-6-37 Accepted 15 April 2009 This article is available from http content 6 1 37 2009 Laufer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Multiple sclerosis-associated retrovirus MSRV RNA sequences have been detected in patients with multiple sclerosis MS and are related to the multi-copy human endogenous retrovirus family type W HERV-W . Only one HERV-W locus ERVWE1 codes for a complete HERV-W Env protein Syncytin-1 . Syncytin-1 and the putative MSRV Env protein have been involved in the pathogenesis of MS. The origin of MSRV and its precise relation to HERV-W were hitherto unknown. Results By mapping HERV-W env cDNA sequences n 332 from peripheral blood mononuclear cells of patients with MS and healthy controls onto individual genomic HERV-W env elements we identified seven transcribed HERV-W env loci in these cells including ERVWE1. .

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