TAILIEUCHUNG - Retrovirology Research BioMed Central Open Access Conservation of Nef function across highly
Retrovirology Research BioMed Central Open Access Conservation of Nef function across highly diverse lineages of SIVsmm Jan Schmökel1, Hui Li2, Elizabeth Bailes3, Michael Schindler1,7, Guido Silvestri4,5, Beatrice H Hahn2, Cristian Apetrei6 and Frank Kirchhoff*1 Address: 1Institute of Virology, University of Ulm, 89081 Ulm, Germany, 2Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA, 3Institute of Genetics, University of Nottingham, Queens Medical Centre NH7 2UH, Nottingham, UK, 4Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia, USA, 5Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19107, USA, 6Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA. | Retrovirology BioMed Central Open Access Conservation of Nef function across highly diverse lineages of SIVsmm Jan Schmokel1 Hui Li2 Elizabeth Bailes3 Michael Schindler1 7 Guido Silvestri4 5 Beatrice H Hahn2 Cristian Apetrei6 and Frank Kirchhoff 1 Address 1Institute of Virology University of Ulm 89081 Ulm Germany - Departments of Medicine and Microbiology University of Alabama at Birmingham Birmingham Alabama 35294 USA Institute of Genetics University of Nottingham Queens Medical Centre NH7 2UH Nottingham UK 4Yerkes Regional Primate Research Center Emory University Atlanta Georgia USA 5Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia Pennsylvania 19107 USA 6Division of Microbiology Tulane National Primate Research Center Covington LA 70433 USA and 7Heinrich-Pette-Institut 20251 Hamburg Germany Email Jan Schmokel - Hui Li - hli@ Elizabeth Bailes - Michael Schindler - Guido Silvestri - gsilvest@ Beatrice H Hahn - bhahn@ Cristian Apetrei - crapetrei@ Frank Kirchhoff - Corresponding author Published 9 April 2009 Received 7 December 2008 Retrovirology 2009 6 36 doi 1742-4690-6-36 Accepted 9 April 2009 This article is available from http content 6 1 36 2009 Schmokel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background SIVsmm is a simian immunodeficiency virus that persists efficiently without causing disease in naturally infected sooty mangabeys SMs but induces AIDS upon cross-species transmission to humans and macaques. Current phylogenetic data indicate that SIVsmm .
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