TAILIEUCHUNG - Retrovirology Research BioMed Central Open Access Isolation and characterization of a small
Retrovirology Research BioMed Central Open Access Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology Samir Abdurahman1, Ákos Végvári3, Michael Levi2, Stefan Höglund4, Marita Högberg5, Weimin Tong5, Ivan Romero5, Jan Balzarini6 and Anders Vahlne*1 Address: 1Division of Clinical Microbiology, Karolinska Institutet, F68 Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden, 2Tripep AB, Hälsovägen 7, SE-141 57 Huddinge, Sweden, 3Department of Electrical Measurements, Lund University, SE-221 00 Lund, Sweden, 4Department of Biochemistry, Uppsala University, SE-751 23 Uppsala, Sweden, 5Chemilia AB, SE-141 83 Huddinge, Sweden and 6Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium Email: Samir Abdurahman - ; Ákos. | Retrovirology BioMed Central Research Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology Samir Abdurahman1 Ákos Végvári3 Michael Levi2 Stefan Hoglund4 Marita Hogberg5 Weimin Tong5 Ivan Romero5 Jan Balzarini6 and Anders Vahlne 1 Address division of Clinical Microbiology Karolinska Institutet F68 Karolinska University Hospital Huddinge SE-141 86 Stockholm Sweden 2Tripep AB Halsovagen 7 SE-141 57 Huddinge Sweden 3Department of Electrical Measurements Lund University SE-221 00 Lund Sweden 4Department of Biochemistry Uppsala University SE-751 23 Uppsala Sweden 5Chemilia AB SE-141 83 Huddinge Sweden and 6Rega Institute for Medical Research Katholieke Universiteit Leuven Minderbroedersstraat 10 B-3000 Leuven Belgium Email Samir Abdurahman - Ákos Végvári - Michael Levi - Stefan Hoglund - Marita Hogberg - Weimin Tong - Ivan Romero - Jan Balzarini - Anders Vahlne - Corresponding author Open Access Published 8 April 2009 Received 22 December 2008 Retrovirology 2009 6 34 doi 1742-4690-6-34 Accepted 8 April 2009 This article is available from http content 6 1 34 2009 Abdurahman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Formation of an HIV-1 particle with a conical core structure is a prerequisite for the subsequent infectivity of the virus particle. We have previously described that glycineamide G-NH2 when added to the culture medium of infected cells induces non-infectious HIV-1 particles with aberrant core
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