TAILIEUCHUNG - Báo cáo khoa học: "Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunctio"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. | Available online http content 8 4 R234 Research Procalcitonin and C-reactive protein during systemic inflammatory response syndrome sepsis and organ dysfunction Gian Paolo Castelli1 Claudio Pognani1 Michael Meisner2 Antonio Stuani1 Daniela Bellomi3 and Laura Sgarbi1 Open Access intensive Care Anesthesiology and Pain Relief Unit C Poma Hospital Mantova Italy 2Department of Anaesthesiology and Intensive Care Therapy University of Jena Germany 3Clinical Pathology Laboratory C Poma Hospital Mantova Italy Corresponding author Gian Paolo Castelli Received 22 November 2003 Revisions requested 24 November 2003 Revisions received 22 April 2004 Accepted 4 May 2004 Published 10 June 2004 Critical Care 2004 8 R234-R242 DOI cc2877 This article is online at http content 8 4 R234 2004 Castelli et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction Both C-reactive protein CRP and procalcitonin PCT are accepted sepsis markers. However there is still some debate concerning the correlation between their serum concentrations and sepsis severity. We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response. Patients and methods One hundred and fifty adult intensive care unit patients were observed consecutively over a period of 10 days. PCT CRP and infection parameters were compared among the following groups no systemic inflammatory response syndrome SIRS n 15 SIRS n 15 sepsis SS n 71 including sepsis severe sepsis and septic shock n 34 n 22 and n 15 and trauma patients n 49 no infection . Results PCT and CRP concentrations were higher in patients in whom infection was diagnosed at comparable levels

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