TAILIEUCHUNG - Báo cáo y học: " From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development. | http content 1 1 030 Review From fruitflies to mammals mechanisms of signalling via the Sonic hedgehog pathway in lung development Minke van Tuyl and Martin Post Hospital for Sick Children Research Institute Toronto and University of Toronto Toronto Canada Received 17 May 2000 Revisions requested 1 June 2000 Revisions received 7 June 2000 Accepted 7 June 2000 Published 20 June 2000 Respir Res 2000 1 30-35 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling. Keywords Gli proteins lung development patched Sonic hedgehog Introduction During development the mammalian lung establishes a large diffusible interface with the circulation to facilitate respiratory gas exchange at term. In the human the appearance of a midventral groove in the single foregut tube just posterior to the pharynx at around the fourth week of human development is the first sign of lung formation. Next the laryngo-tracheal groove deepens and finally constricts thereby dividing the foregut tube into a ventral trachea and a dorsal esophagus. At the same time the tracheal rudiment outgrowth elongates caudally and bifurcates to form two bronchial lung buds. In the mouse the lung starts as a tracheal diverticulum in the ventral half of the primitive foregut just anterior to the developing stomach at days of gestation. The two lung buds elongate in a posterior-ventral direction. At the same time starting at the primary branching point the single foregut tube begins to divide into .

TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.