TAILIEUCHUNG - Báo cáo khoa hoc : Protein alpha-N-acetylation studied by N-terminomics

Cotranslational protein N-terminal modifications, including proteolytic maturation such as initiator methionine excision by methionine aminopep-tidases and N-terminal blocking, occur universally. Protein alpha-N-acety-lation, or the transfer of the acetyl moiety of acetyl-coenzyme A to nascent protein N-termini | IFEBS Journal REVIEW ARTICLE Protein alpha-N-acetylation studied by N-terminomics Petra Van Damme1 2 Thomas Arnesen3 4 and Kris Gevaert1 2 1 Department of MedicalProtein Research VIB Ghent Belgium 2 Department of Biochemistry Ghent University Belgium 3 Department of Molecular Biology University of Bergen Norway 4 Department of Surgery Haukeland University Hospital Bergen Norway Keywords acetyl-coenzyme A alternative translation initiation sites alpha-N-acetylation combined fractional diagonal chromatography cotranslational modification N-acetylome N-terminal acetyltransferase N-terminomics positional proteomics protein N-termini Correspondence K. Gevaert P. Van Damme VIB Department of MedicalProtein Research UGent Faculty of Medicine and Health Sciences Ghent University A. Baertsoenkaai 3 B-9000 Ghent Belgium Fax 32 92 649 496 Tel 32 92 649 274 E-mail Cotranslational protein N-terminal modifications including proteolytic maturation such as initiator methionine excision by methionine aminopeptidases and N-terminal blocking occur universally. Protein alpha-N-acety-lation or the transfer of the acetyl moiety of acetyl-coenzyme A to nascent protein N-termini catalysed by multisubunit N-terminal acetyltransferase complexes generally takes place during protein translation. Nearly all protein modifications are known to influence different protein aspects such as folding stability activity and localization and several studies have indicated similar functions for protein alpha-N-acetylation. However until recently protein alpha-N-acetylation remained poorly explored mainly due to the absence of targeted proteomics technologies. The recent emergence of N-terminomics technologies that allow isolation of protein N-terminal peptides together with proteogenomics efforts combining experimental and informational content have greatly boosted the field of alpha-N-acetylation. In this review we report on such emerging technologies

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