TAILIEUCHUNG - Báo cáo khoa hoc : Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease

Glutathione (GSH) conjugating enzymes, glutathioneS-transferases (GSTs), are present in different subcellular compartments including cytosol, mitochondria, endoplasmic reticulum, nucleus and plasma membrane. The regulation and function of GSTs have implications in cell growth, oxidative stress as well as disease progression and prevention. | fFEBS Journal MINIREVIEW Dual localization of glutathione S-transferase in the cytosol and mitochondria implications in oxidative stress toxicity and disease Haider Raza Department of Biochemistry Faculty of Medicine and Health Sciences UAE University Al Ain UAE Keywords chemical toxicity cryptic mitochondrial signal dual localization of GSTs glutathione S-transferase Hsp70 chaperone N-terminal signal region oxidative stress PKA phosphorylation Correspondence Haider Raza Department of Biochemistry Faculty of Medicine and Health Sciences UAE University PO Box 17666 Al An UAE. Fax 971 3 7672033 Tel 971 3 7137506 E-mail Received 19 May 2011 revised 12 August 2011 accepted 12 September 2011 doi Glutathione GSH conjugating enzymes glutathione S-transferases GSTs are present in different subcellular compartments including cytosol mitochondria endoplasmic reticulum nucleus and plasma membrane. The regulation and function of GSTs have implications in cell growth oxidative stress as well as disease progression and prevention. Of the several mitochondria localized forms GSTK GST kappa is mitochondria-specific since it contains N-terminal canonical and cleavable mitochondria targeting signals. Other forms like GST alpha mu and pi purified from mitochondria are similar to the cytosolic molecular forms or echoproteins . Altered GST expression has been implicated in hepatic cardiac and neurological diseases. Mitochondria-specific GSTK has also been implicated in obesity diabetes and related metabolic disorders. Studies have shown that silencing the GSTA4 GST alpha gene resulted in mitochondrial dysfunction as was also seen in GSTA4 null mice which could contribute to insulin resistance in type 2 diabetes. This review highlights the significance of the mitochondrial GST pool particularly the mechanism and significance of dual targeting of GSTA4-4 under in vitro and in vivo conditions. GSTA4-4 is targeted in the mitochondria by .

• Báo cáo khoa học
• Biochemistry
• molecular Biology
• biological cells
• oxidative stress
• S transferase
• Scientific reports
• Textbook of biochemistry
• Chemical basis of life
• General metabolism
• Clinical and applied biochemistry
• Applied biochemistry
• Chemistry of lipids
• Chemistry of carbohydrates
• Overview of metabolism
• Advanced biochemistry
• Steroid hormones
• Control of gene expression
• Principles of biochemistry
• Lecture Principles of biochemistry
• Biological systems
• Biochemical compounds
• Biological macromolecules
• Chemical principles
• Ebook Principles of biochemistry
• Principles of biochemistry (4th edition)
• The glyoxylate cycle
• Fatty acid catabolism
• Electron Transfer reactions
• Evolutionary foundations
• Protein interactions modulated
• Nucleic acid structure
• Ebook Plant biochemistry
• Plant biochemistry
• Plant biochemistry (Third edition)
• Several metabolic compartments
• The plant cell mechanical
• The chlorophyll molecule
• Nodule forming bacteria
• The amino acids
• The endoplasmic reticulum
• Special topics
• Harper’s illustrated biochemistry
• Replication of informational macromolecules
• Biochemistry of extracellular
• Intracellular communication
• Illustrated biochemistry
• Biochemical case histories
• The biochemistry of aging
• Signal transduction
• Hormone action
• Clinical biochemistry
• Analytical BioChemistry
• Preparation Techniques
• Analytical Chemistry
• chemical analysis
• the overall chemical analysis
• chemical analysis of materials
• General biochemistry
• biochemistry lectures
• animal biochemistry
• biochemical
• dynamic
• static biochemical
• cell membranes
• Biotechnology Biochemistry
• Algae Anatomy
• Biotechnology
• Glaucophyta
• Endosymbiosis and Origin
• Axoneme
• Lehninger principles of biochemistry
• The foundations of biochemistry
• Structure and catalysis
• The three dimensional structure of proteins
• Carbohydrates and glycobiology
• Protein function
• BRS biochemistry molecular biology
• Fuel metabolism
• Basic principles
• Basic aspects of biochemistry
• Acid–base chemistry
• Gene expression
• Synthesis of proteins
• Properties of water
• Hydrogen bonding
• Amino acids
• Amino acid structure
• Protein purification
• Cell extract
• Protein classification
• Protein 3 Dimensional structure
• Protein folding
• Protein 3 D structure
• 3 D structure
• Oxygen binding curve
• Enzyme kinetics
• Rate constants
• Catalytic Power
• Classes of enzymes
• Inhibitor kinetics
• Enzyme regulation
• Allosteric regulation
• Enzyme action
• Mechanisms of enzyme action