TAILIEUCHUNG - Báo cáo y học: " Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model. | Respiratory Research BioMed Central Research Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model Sukhjit S Gill 1 Sarabjeet S Suri 1 Kyathanahalli S Janardhan1 Sarah Caldwell1 Tanya Duke1 2 and Baljit Singh 1 Address Department of Veterinary Biomedical Sciences University of Saskatchewan Saskatoon SK S7N5B4 Canada and 2Department of Small Animal Clinical Sciences University of Saskatchewan Saskatoon SK S7N5B4 Canada Email Sukhjit S Gill - sukhjeet_gill@ Sarabjeet S Suri - Kyathanahalli S Janardhan - kjanardh@ Sarah Caldwell - Tanya Duke - Baljit Singh - Corresponding author fEqual contributors Open Access Published 24 October 2008 Respiratory Research 2008 9 69 doi 1465-9921 -9-69 Received 10 August 2008 Accepted 24 October 2008 This article is available from http content 9 1 69 2008 Gill et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bile-duct ligated BDL rats recruit pulmonary intravascular macrophages PIMs and are highly susceptible to endotoxin-induced mortality. The mechanisms of this enhanced susceptibility and mortality in BDL rats which are used as a model of hepato-pulmonary syndrome remain unknown. We tested a hypothesis that recruited PIMs promote endotoxin-induced mortality in a rat model. Methods Rats were subjected to BDL to induce PIM recruitment followed by treatment with gadolinium chloride GC to deplete PIMs. Normal and BDL rats were treated intravenously with E. coli lipopolysaccharide LPS with or without GC pre-treatment followed by collection and analyses of lungs for .

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