TAILIEUCHUNG - Báo cáo y học: "Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity. | Available online http content 8 4 R102 Research article Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity Stefan Carlsen Kutty Selva Nandakumar and Rikard Holmdahl Open Access Medical Inflammation Research BMC I11 Lund University SE-221 84 Lund Sweden Corresponding author Rikard Holmdahl Received 30 Mar 2006 Revisions requested 10 May 2006 Revisions received 26 May 2006 Accepted 6 Jun 2006 Published 3 Jul 2006 Arthritis Research Therapy 2006 8 R102 doi ar1989 This article is online at http content 8 4 R102 2006 Carlsen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Joint cartilage is attacked in both autoimmune inflammatory and osteoarthritic processes. Type IX collagen CIX is a protein of importance for cartilage integrity and stability. In this study we have backcrossed a transgenic disruption of the col9a1 gene which leads to an absence of CIX into two different inbred mouse strains DBA 1 and . None of the ClX-deficient mice developed observable clinical or microscopic osteoarthritis but DBA 1 male mice had more pronounced enthesopathic arthritis the so-called stress-induced arthritis. Both DBA 1 and strains are susceptible to the induction of collagen-induced arthritis and CIX deficiency in both strains led to the development of a more severe arthritis than in the controls. Induction of arthritis with monoclonal antibodies against type II collagen Cll led to an earlier arthritis in the paws that also involved the knee joints. The antibodies used which were specific for the J1 and the C1I epitopes of CII initiate their arthritogenic attack by binding to .

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