TAILIEUCHUNG - Clinical trials in gynecological cancer

Specific micronutrient deficiencies may affect maternal and foetal health. Iodine deficiency during pregnancy may cause foetal brain damage and mental retardation in infants. Vitamin A deficiency increases the risk in pregnant women of infection and anaemia, may cause blindness during pregnancy and early lactation, and has been associated to an elevated risk of HIV mother-to-child transmission. Folate deficiency may cause severe foetal neural tube defects like anencephaly and spina bifida. Iron deficiency weakens the maternal body, impairs intrauterine growth and increases the risk of both maternal and foetal morbidity and mortality (World Health Organization 2000a). . | Int J Gynecol Cancer 2007 17 547-556 REVIEW PAPER Clinical trials in gynecological cancer . TRIMBLE J. DAVIS P. DISAIA K. FUJIWARA D. GAFFNEY G. KRISTENSEN J. LEDERMAnN J. PFISTERER M. QUInN N. reed M. SCHOENFELDT . THIGPEN ON BEHALF OF THE GYNECOLOGIC CANCER INTERGROUP National Cancer Institute Cancer Therapy Evaluation Program North Glasgow University Hospitals NHS Trust University of California Medical Center at Irvine Saitama Medical University Huntsman Cancer Hospital University of Utah Norwegian Radium Hospital Cancer Research UK and UCL Cancer Trials Centre Universitatsklinikum Schleswig-Holstein Campus Kiel University of Melbourne Beatson Oncology Centre The EMMES Corporation and University of Mississippi School of Medicine Abstract. Trimble EL Davis J DiSaia P Fujiwara K Gaffney D Kristensen G Ledermann J Pfisterer J Quinn M Reed N Schoenfeldt M Thigpen JT on behalf of the Gynecologic Cancer Intergroup . Clinical trials in gynecological cancer. Int J Gynecol Cancer 2007 17 547-556. The Gynecologic Cancer Intergroup is comprised representatives from international gynecological cancer trials organizations which collaborate in multicenter studies to answer the clinical challenges in gynecological cancer. This review article highlights the key clinical questions facing clinical trialists over the next decade the information and infrastructure resources available for trials and the methods of trial development. We cover human papillomavirus HPV -associated neoplasia including cervical cancer together with endometrial cancer ovarian cancer and vulvar cancer. Infrastructure for clinical trials includes a database for trials templates for protocol development patient educational material and financial support for clinical trials. Other critical issues include support from government and charities and government regulations. keywords gynecologic cancer ovarian cancer cervical cancer endometrial cancer clinical trials GCIG. The Gynecologic Cancer Intergroup .

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