TAILIEUCHUNG - Báo cáo khoa học: Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet

Leaf extract ofGinkgo biloba(GBE) is increasingly used as a herbal medi-cine for the treatment of neurodegenerative, cardiovascular and cerebrovas-cular diseases. Several studies have demonstrated many protective effects of GBE in neurons, the endothelium and liver. | Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet Xiaomei Gu1 Zuoquan Xie2 Qi Wang1 Gang Liu1 Yi Qu1 Lu Zhang1 2 Jiahu Pan3 Guoping Zhao1 4 and Qinghua Zhang1 2 4 1 NationalEngineering Center for Biochip at Shanghai China 2 State Key Laboratory of MedicalGenomics and Shanghai Institute of Hematology Ruijin Hospital Shanghai Jiaotong University Schoolof Medicine China 3 Schoolof Pharmacy Fudan University Shanghai China 4 MOST-Shanghai Key Laboratory of Disease and Health Related Genomics China Keywords Ginkgo biloba extract high-fat diet rat liver regulation transcriptome Correspondence Q. Zhang State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology Ruijin Hospital Shanghai Jiaotong University Schoolof Medicine Shanghai 200025 China Fax 86 21 51320266 Tel 86 21 51320288 E-mail qinghua_zhang@ These authors contributed equally to this work Received 8 September 2008 revised 29 December 2008 accepted 5 January 2009 doi Leaf extract of Ginkgo biloba GBE is increasingly used as a herbal medicine for the treatment of neurodegenerative cardiovascular and cerebrovascular diseases. Several studies have demonstrated many protective effects of GBE in neurons the endothelium and liver. In this study we investigated the molecular mechanisms underlying the effects of GBE in disorders induced by long-term exposure to a high-fat diet HFD . Rats were fed an HFD with or without the GBE product GBE50 for 19 weeks. We found that GBE50 reduced the development of fatty liver induced by an HFD and inhibited the commonly observed elevation of serum cholesterol and lactate dehydrogenase levels. Transcriptome profiling analysis showed that several genes were modulated by GBE50 in liver including those involved in lipid metabolism carbohydrate metabolism vascular constriction ion transportation neuronal systems and drug metabolism. Notably a .

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