TAILIEUCHUNG - Báo cáo y học: "The Changing Microbial Environment and Chronic Inflammatory Disorders"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The Changing Microbial Environment and Chronic Inflammatory Disorders. | ORIGINAL ARTICLE The Changing Microbial Environment and Chronic Inflammatory Disorders Graham . Rook BA MB BChir MD There is much to be gained from examining human diseases within the expanding framework of Darwinian medicine. This is particularly true of those conditions that change in frequency as populations develop from the human environment of evolutionary adaptedness to the living conditions of the rich industrialized countries. This development entails major changes in lifestyle leading to reductions in contact with environmental microorganisms and helminths that have evolved a physiologic role as drivers of immunoregulatory circuits. It is suggested that a deficit in immunoregulation in rich countries is contributing not only to increases in the incidence of allergic disorders but also to increases in other chronic inflammatory conditions that are exacerbated by a failure to terminate inappropriate inflammatory reponses. These include autoimmunity neuroinflammatory disorders atherosclerosis depression associated with raised inflammatory cytokines and some cancers. in 1989 Strachan showed that in young adults a history of hay fever was inversely related to the number of children in the family when the subject was 11-years Further studies suggested that having many siblings especially older ones correlated with diminished risk of hay fever and these findings were considered consistent with a protective influence of postnatal infection which might be lost in the presence of modern So the hygiene hypothesis was born. The concept was initially vague and lacked mechanistic explanations so in the 28 years since the original study a multitude of different often mutually exclusive versions of this hypothesis have been considered. Often this has led to the disproving of hypotheses that few had intended to propose in the first place. However during the last 9 years an essentially new hypothesis has emerged which we have preferred to designate the .

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