TAILIEUCHUNG - Báo cáo y học: "GOAL: What Have We Learned"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: GOAL: What Have We Learned? | Editorial GOAL What Have We Learned Timothy K. Vander Leek MD FRCPC A recent study entitled Can Guideline-Defined Asthma Control Be Achieved 1 stands out as one of the most noteworthy clinical studies of the past year because of the important concepts it confirms and because of the many significant questions it raises. Published online in July 2004 and in print in October of the same year it is referred to by most as the GOAL trial from the now familiar acronym for Gaining Optimal Asthma controL . Based on what we have learned from the GOAL trial it is likely that the next iteration of asthma guidelines will be somewhat more stringent in their acceptance of symptoms that define well-controlled asthma or acceptable control. To fully appreciate the study it is necessary to highlight two previous hypothesis-generating studies2 3 that led to the development of the GOAL trial protocol. In the first of the two studies the authors pooled data from eight trials using inhalers containing combined salmeterol and fluticasone The data were reanalyzed with a new endpoint based on a composite measurement of asthma control as defined in guidelines published by the Global Initiative for Asthma GINA . This was the first time a composite endpoint based on current asthma guidelines was used as opposed to the majority of asthma studies to date which have selected single-variable endpoints. The results of this analysis indicated that guideline-defined asthma control can be achieved and led to the development of a prospective protocol using the composite measure as the endpoint. The second Division of Clinical Immunology and Allergy Department of Pediatrics University of Alberta Edmonton Alberta Correspondence to Timothy K. Vander Leek MD 903 College Plaza 8215-112 St. Edmonton AB T6G 2C8 E-mail timvanderleek@ hypothesis-generating study also indicated that improved quality of life was realized as the level of control improved control again being defined by a .

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