TAILIEUCHUNG - báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis | Journal of Experimental Clinical Cancer Research Lin et al. Journal of Experimental Clinical Cancer Research 2011 30 31 http content 30 1 31 RESEARCH Open Access Expression of Ets-1 Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis Zijing Lin Yu Liu Yuhui Sun1 Xiuping He Abstract Background Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role in angiogenesis remodeling of extracellular matrix and tumor metastasis. Ets-1 target genes involved in various stages of new blood vessel formation include angiopoietin matrix metalloproteinases MMPs and the protease inhibitor maspin. Methods We used immunohistochemistry IHC to detect the expression of Ets-1 angiopoietin-2 Ang-2 and maspin in ovarian tumor and analyzed the relationship between the expression of these proteins and the clinical manifestation of ovarian cancer. Results Ets-1 expression was much stronger in ovarian cancer compared to benign tumors but had no significant correlation with other pathological parameters of ovarian cancer. However Ang-2 and maspin expression had no obvious correlation with pathological parameters of ovarian cancer. Ets-1 had a positive correlation with Ang-2 which showed their close relationship in angiogenesis. Although microvessel density MVD value had no significant correlation with the expression of Ets-1 Ang-2 or maspin strong nuclear expression of maspin appeared to be correlated with high grade and MVD. Conclusions The expression of Ets-1 Ang2 and maspin showed close relationship with angiogenesis in ovarian cancer and expression of maspin appeared to be correlated with high grade and MVD. The mechanisms underlying the cross-talk of the three factors need further investigations. Background Ovarian cancer is the sixth most common cancer and the sixth most frequent cause of cancer death in women. It is the leading cause of death from gynecologic cancer in women in industrialized .

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