TAILIEUCHUNG - Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects

To represent the specific behaviors of this reflection, a schematic model was sought that simultaneously covered health promotion and the Health Policy for the Elderly, with a view to adopting actions for greater awareness, resulting in attitudes of empowerment and suggestions for gerontogeriatric nursing actions. Nola Pender s Health Promotion Model(10) was used. Through a chart, it manages to represent the behaviors that can lead to health promotion. Nola Pender s Model was developed in the United States in the 1980s, but was little explored in Brazil. It emerges as a proposal to integrate behavioral sciences with nursing theories, seeking to identify factors that influence health behaviors in a biopsychosocial context. It seeks to support its. | ORIGINAL CONTRIBUTION Cognitive and Physiologic Correlates of Subclinical Structural Brain Disease in Elderly Healthy Control Subjects Ian A. Cook MD Andrew F. Leuchter MD Melinda L. Morgan PhD Elise Witte Conlee PhD Steven David Robert Lufkin MD Ashkan Babaie MD Jennifer J. Dunkin PhD Ruth O Hara PhD Sara Simon PhD Amy Lightner MD Susan Thomas MD David Broumandi MD Neeraj Badjatia MD Laura Mickes Rajal K. Mody MD Sanjaya Arora MD Zimu Zheng MD Michelle Abrams RN Susan Rosenberg-Thompson MSN Context Healthy elderly persons commonly show 4 types of change in brain structure cortical atrophy central atrophy deep white-matter hyperintensities and periventricular hyperintensities as forms of subclinical structural brain disease SSBD . Objectives To characterize the volumes of SSBD present with aging and to determine the associations of SSBD physiology and cognitive function. Design Cross-sectional study. Setting University of California Los Angeles Neuropsychiatric Institute. Subjects Forty-three community-dwelling healthy control subjects aged 60 through 93 years. Main Outcome Measures Volumetric magnetic resonance imaging neuropsychological testing and quantitative electroencephalographic coherence functional connectivity between brain regions. Results Regression models demonstrated significant relationships between SSBD volumes age cognitive performance and connectivity. Cortical and central atro phy and periventricular hyperintensities had significant associations with age while deep white-matter hyperintensities did not. Posterior atrophy showed stronger associations with age than did anterior atrophy. Only a subset of subjects at older ages showed large SSBD volumes older subjects primarily showed increasing variance of SSBD. Although all subjects scored within the normal range on cognitive testing SSBD volume was inversely related to performance most notably on the TrailMaking Test part B and the Shipley-Hartford Abstract Reasoning test. Coherence had .

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