TAILIEUCHUNG - Báo cáo khoa học: Branched N-glycans regulate the biological functions of integrins and cadherins

Glycosylation is one of the most common post-translational modifications, and approximately 50% of all proteins are presumed to be glycosylated in eukaryotes. Branched N-glycans, such as bisecting GlcNAc,b-1,6-GlcNAc and core fucose (a-1,6-fucose), are enzymatic products of N-acetylglucos-aminyltransferase III,N-acetylglucosaminyltransferase V and a-1,6-fucosyl-transferase, respectively. | ỊFEBS Journal REVIEW ARTICLE Branched N-glycans regulate the biological functions of integrins and cadherins Yanyang Zhao1 2 Yuya Sato3 Tomoya Isaji3 Tomohiko Fukuda3 Akio Matsumoto2 Eiji Miyoshi1 Jianguo Gu3 and Naoyuki Taniguchi2 1 Department of Biochemistry Osaka University Graduate Schoolof Medicine Japan 2 Department of Disease Glycomics Research Institute for MicrobialDiseases Osaka University Japan 3 Division of Regulatory Glycobiology Institute of Molecular Biomembrane and Glycobiology Tohoku PharmaceuticalUniversity Sendai Miyagi Japan Keywords cancer metastasis cell adhesion E-cadherin Fut8 glycosyltransferase GnT-III GnT-V integrin N-glycan N-glycosylation Correspondence N. Taniguchi Department of Disease Glycomics Research Institute for Microbial Diseases Osaka University Osaka 565-0871 Japan Tel Fax 81 6 6879 4137 E-mail tani52@ J. Gu Division of Regulatory Glycobiology Institute of Molecular Biomembrane and Glycobiology Tohoku Pharmaceutical University Sendai Miyagi 981-8558 Japan Fax 81 22 1727 0078 Tel 81 22 1727 0216 E-mail jgu@ Glycosylation is one of the most common post-translational modifications and approximately 50 of all proteins are presumed to be glycosylated in eukaryotes. Branched N-glycans such as bisecting GlcNAc b-1 6-GlcNAc and core fucose a-1 6-fucose are enzymatic products of N-acetylglucos-aminyltransferase III N-acetylglucosaminyltransferase V and a-1 6-fucosyl-transferase respectively. These branched structures are highly associated with various biological functions of cell adhesion molecules including cell adhesion and cancer metastasis. E-cadherin and integrins bearing N-glycans are representative adhesion molecules. Typically both are glycosylated by N-acetylglucosaminyltransferase III which inhibits cell migration. In contrast integrins glycosylated by N-acetylglucosaminyltrans-ferase V promote cell migration. Core fucosylation is essential for integrin-mediated cell migration and signal .

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