TAILIEUCHUNG - Báo cáo khoa học: Parkinson’s disease: genetic versus toxin-induced rodent models

Parkinson’s disease (PD), a common progressive neurodegenerative disor-der, is characterized by degeneration of dopamine neurons in the substantia nigra and neuronal proteinaceous aggregates called Lewy bodies (LBs). The etiology of PD is probably a combination of environmental and genetic factors. | MINIREVIEW Parkinson s disease genetic versus toxin-induced rodent models Mugen Terzioglu1 and Dagmar Galter2 1 Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden 2 Department of Neuroscience Karolinska Institutet Stockholm Sweden Keywords 6-OHDA conditional knockout mice DAT-cre dopamine system Engrailed intracellular aggregates mitochondrial dysfunction MPTP PARK genes progressive neurodegeneration a-synuclein Correspondence D. Galter Department of Neuroscience Karolinska Institutet Retzius vag 8 171 77 Stockholm Sweden Fax 46 8 32 37 42 Tel 46 8 524 87018 E-mail Received 23 October 2007 revised 17 December 2007 accepted 7 January 2008 doi Parkinson s disease PD a common progressive neurodegenerative disorder is characterized by degeneration of dopamine neurons in the substantia nigra and neuronal proteinaceous aggregates called Lewy bodies LBs . The etiology of PD is probably a combination of environmental and genetic factors. Recent progress in molecular genetics has identified several genes causing PD including a-synuclein leucine-rich repeat kinase 2 LRRK2 Parkin DJ-1 and PTEN-induced kinase 1 PINK1 many of them coding for proteins found in LBs and or implicated in mitochondrial function. However the mechanism s leading to the development of the disease have not been identified despite intensive research. Animal models help us to obtain insights into the mechanisms of several symptoms of PD allowing us to investigate new therapeutic strategies and in addition provide an indispensable tool for basic research. As PD does not arise spontaneously in animals characteristic and specific functional changes have to be induced by administration of toxins or by genetic manipulations. This review will focus on the comparison of three types of rodent animal models used to study different aspects of PD a animal models using neurotoxins b genetically modified mouse models reproducing findings from .

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