TAILIEUCHUNG - Báo cáo sinh học: "Reasons for breast cancer heterogeneity"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Reasons for breast cancer heterogeneity. | Journal of Biology BioMed Central Minireview Reasons for breast cancer heterogeneity Francois Bertucci and Daniel Birnbaum Address Centre de Recherche en Cancérologie de Marseille Laboratoire d Oncologie Moléculaire UMR891 Inserm Institut Paoli-Calmettes Université de la Méditerranée 13009 Marseille France. Correspondence Daniel Birnbaum. Email birnbaum@ Published 22 February 2008 Journal of Biology 2008 7 6 doi jbiol67 The electronic version of this article is the complete one and can be found online at http content 7 2 6 2008 BioMed Central Ltd Abstract Breast cancers differ in many ways such as in their cell of origin the molecular alterations causing them and the susceptibility and defenses of the patient and this makes it difficult to give the most appropriate treatment. Two recent papers have contributed to the establishment of a more precise molecular classification of breast tumors. Breast cancer is a heterogeneous disease that comes in several clinical and histological forms. Its clinical progression is difficult to predict using the current prognostic factors and its treatment is therefore not as effective as it should be. Mortality due to breast cancer is decreasing in most western countries because of mass screening frequent use of post-operative chemotherapy and or hormone therapy and the recent introduction of new drugs. However novel drugs and therapeutic strategies could be more successful if we understood breast cancer heterogeneity better. Two recent papers in Genome Biology from the laboratories of Carlos Caldas 1 and Eric Miska 2 use molecular methods to classify breast cancers more precisely. Breast cancer heterogeneity Because breast cancer heterogeneity arises from many different factors several directions of research must be pursued simultaneously if we are to understand and cope with the different forms of breast cancer. These are to determine the cell of origin to determine the molecular alteration s to

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