TAILIEUCHUNG - Báo cáo khoa học: KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases

Potassium channel tetramerization domain (KCTD) proteins contain a bric-a-brac, tramtrak and broad complex (BTB) domain that is most simi-lar to the tetramerization domain (T1) of voltage-gated potassium chan-nels. | KCTD5 a putative substrate adaptor for cullin3 ubiquitin ligases Yolanda Bayon1 Antonio G. Trinidad1 Maria L. de la Puerta1 Maria del Carmen Rodríguez1 Jori Bogetz2 Ana Rojas3 Jose M. De Pereda4 Souad Rahmouni5 Scott Williams2 Shu-ichi Matsuzawa6 John C. Reed6 Mariano Sanchez Crespo1 Tomas Mustelin2 and Andrei s Alonso1 1 Institute de Biología y Genetica Molecular CSIC-Universidad de Valladolid Spain 2 Program of Inflammation Inflammatory and Infectious Disease Center and Program of SignalTransduction Burnham Institute for Medical Research La Jolla CA USA 3 StructuralBioinformatics Group Centro Nacionalde Investigaciones Oncologicas Madrid Spain 4 Centro de Investigacion delCancer CSIC-Universidad de Salamanca Spain 5 Department of Pathology B-35 University of Liege CHU of Liege Belgium 6 Program of Apoptosis and CellDeath Burnham Institute for MedicalResearch La Jolla CA USA Keywords BTB cullin E3 ligases KCTD ubiquitin Correspondence A. Alonso Instituto de Biologia y Genetica Molecular CSIC-Universidad de Valladolid c Sanz y Fores s n 47003 Valladolid Spain Fax 34 983 184800 Tel 34 983 184839 E-mail andres@ Received 7 April2008 revised 30 May 2008 accepted 3 June 2008 doi Potassium channel tetramerization domain KCTD proteins contain a bric-a-brac tramtrak and broad complex BTB domain that is most similar to the tetramerization domain T1 of voltage-gated potassium channels. Some BTB-domain-containing proteins have been shown recently to participate as substrate-specific adaptors in multimeric cullin E3 ligase reactions by recruiting proteins for ubiquitination and subsequent degradation by the proteasome. Twenty-two KCTD proteins have been found in the human genome but their functions are largely unknown. In this study we have characterized KCTD5 a new KCTD protein found in the cytosol of cultured cell lines. The expression of KCTD5 was upregulated post-trans-criptionally in peripheral blood lymphocytes stimulated .

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