TAILIEUCHUNG - Chapter 092. Testicular Cancer (Part 6)

Fertility Infertility is an important consequence of the treatment of GCTs. Preexisting infertility or impaired fertility is often present. Azoospermia and/or oligospermia are present at diagnosis in at least 50% of patients with testicular GCTs. Ejaculatory dysfunction is associated with RPLND, and germ cell damage may result from cisplatin-containing chemotherapy. Nerve-sparing techniques to preserve the retroperitoneal sympathetic nerves have made retrograde ejaculation less likely in the subgroups of patients who are candidates for this operation. Spermatogenesis does recur in some patients after chemotherapy. However, because of the significant risk of impaired reproductive capacity, semen analysis and cryopreservation of sperm. | Chapter 092. Testicular Cancer Part 6 Fertility Infertility is an important consequence of the treatment of GCTs. Preexisting infertility or impaired fertility is often present. Azoospermia and or oligospermia are present at diagnosis in at least 50 of patients with testicular GCTs. Ejaculatory dysfunction is associated with RPLND and germ cell damage may result from cisplatin-containing chemotherapy. Nerve-sparing techniques to preserve the retroperitoneal sympathetic nerves have made retrograde ejaculation less likely in the subgroups of patients who are candidates for this operation. Spermatogenesis does recur in some patients after chemotherapy. However because of the significant risk of impaired reproductive capacity semen analysis and cryopreservation of sperm in a sperm bank should be recommended to all patients before treatment. Further Readings Bosl GJet al Testicular germ-cell cancer. N Engl J Med 337 242 1997 PMID 9227931 -------------et al Cancer of the testis in Cancer Principles and Practice of Oncology 7th ed VT DeVita et al eds . Philadelphia Lippincott Williams Wilkins 2005 pp 1269-1294 Chaganti RSK Houldsworth J Genetics and biology of human male germ cell tumors. Cancer Res 60 1475 2000 PMID 10749107 International Germ Cell Cancer Consensus Group International Germ Cell Consensus Classification A prognostic factor-based staging system for metastatic germ cell cancers. J Clin Oncol 15 594 1997 Kondagunta GV et al Etoposide and cisplatin chemotherapy for metastatic good-risk germ cell tumors. J Clin Oncol 23 9290 2005 PMID 16361627 Moore CJ et al Management of difficult germ-cell tumors. Oncology 20 1565 2006 PMID 17153909 Motzer R et al Sequential dose-intensive paclitaxel ifosfamide carboplatin and etoposide salvage therapy for germ cell tumor patients. J Clin Oncol 18 1173 2000 PMID 10715285 Sonpaude G et al Management of recurrent testicular germ cell tumors. Oncologist 12 51 2007 Bibliography Bosl GJ et al Clinical relevance of the i 12p .

• Y học thường thức
• Testicular Cancer
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu y khoa
• Harrisons Internal Medicine
• BMC Cancer
• Testicular cancer survivors
• Germ cell tumors
• Premature aging
• Molecular aging
• Patient education websites
• Germ cell tumor
• Testicular malignancy
• Testicular germ cell tumour
• Non seminoma
• Frequent cannabis
• Tumor inflitrating neutrophil
• Prognostic value
• Testicular germ cell tumors
• Overall survival
• Health belief model
• Fasa city
• Social support
• Testicular self examination
• Cancer survivors
• Metabolic syndrome
• Cardio metabolic risk factors
• Racial differences
• Highest incidence rates
• Asians and Pacific Islanders
• Testicular germ cell cancer
• Cisplatin sensitivity
• Germ neoplasia in situ
• Undergo malignant transformation
• Mild Leydig cell insufficiency
• Testosterone substitution
• Hormonal disturbance
• Physical activity
• Increased adult height
• Risk factor
• Androgenic alopecia
• Prostate cancer
• Testicular germ cell tumor
• Meta analysis
• Health related quality of life
• Psychometric validation
• Patient reported outcome
• Germ cell neoplasia in situ
• Fibrillin 1
• Testicular germ cell tumours
• Cancer pathogenesis
• Nodal and Activin signalling
• Expression of pluripotency factors
• Germ cell cancer
• Germ cells
• Anti tumoral
• Anti angiogenic multikinase inhibitor
• Primary testicular lymphoma
• Diffuse large B cell lymphoma
• Initial treatment
• Therapy outcome
• Systemic chemotherapy
• Pure seminoma
• Semi quantitative score
• Testicular impairment
• Antioxidant enzymes
• Reproductive hormones
• DNA damages