TAILIEUCHUNG - Chapter 082. Infections in Patients with Cancer (Part 7)

Typhlitis Typhlitis (also referred to as necrotizing colitis, neutropenic colitis, necrotizing enteropathy, ileocecal syndrome, and cecitis) is a clinical syndrome of fever and right-lower-quadrant tenderness in an immunosuppressed host. This syndrome is classically seen in neutropenic patients after chemotherapy with cytotoxic drugs. It may be more common among children than among adults and appears to be much more common among patients with acute myelocytic leukemia (AML) or ALL than among those with other types of cancer; a similar syndrome has been reported in patients infected with HIV type 1. Physical examination reveals right-lower-quadrant tenderness, with or without rebound tenderness. . | Chapter 082. Infections in Patients with Cancer Part 7 Typhlitis Typhlitis also referred to as necrotizing colitis neutropenic colitis necrotizing enteropathy ileocecal syndrome and cecitis is a clinical syndrome of fever and right-lower-quadrant tenderness in an immunosuppressed host. This syndrome is classically seen in neutropenic patients after chemotherapy with cytotoxic drugs. It may be more common among children than among adults and appears to be much more common among patients with acute myelocytic leukemia AML or ALL than among those with other types of cancer a similar syndrome has been reported in patients infected with HIV type 1. Physical examination reveals right-lower-quadrant tenderness with or without rebound tenderness. Associated diarrhea often bloody is common and the diagnosis can be confirmed by the finding of a thickened cecal wall on CT MRI or ultrasonography. Plain films may reveal a right-lower-quadrant mass but CT with contrast or MRI is a much more sensitive means of making the diagnosis. Although surgery is sometimes attempted to avoid perforation from ischemia most cases resolve with medical therapy alone. The disease is sometimes associated with positive blood cultures which usually yield aerobic gram-negative bacilli and therapy is recommended for a broad spectrum of bacteria particularly gram-negative bacilli which are likely to be found in the bowel flora . Surgery is indicated in the case of perforation. Clostridium difficile-induced Diarrhea Patients with cancer are predisposed to the development of C. difficile diarrhea Chap. 123 as a consequence of chemotherapy alone. Thus they may have positive toxin tests before receiving antibiotics. Obviously such patients are also subject to C. difficile-induced diarrhea as a result of antibiotic pressure. C. difficile should always be considered as a possible cause of diarrhea in cancer patients who have received antibiotics. Central Nervous System-Specific Syndromes Meningitis The .

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