TAILIEUCHUNG - Chapter 082. Infections in Patients with Cancer (Part 5)

Sweet's syndrome, or febrile neutrophilic dermatosis, was originally described in women with elevated white blood cell (WBC) counts. The disease is characterized by the presence of leukocytes in the lower dermis, with edema of the papillary body. Ironically, this disease now is usually seen in neutropenic patients with cancer, most often in association with acute leukemia but also in association with a variety of other malignancies. Sweet's syndrome usually presents as red or bluish-red papules or nodules that may coalesce and form sharply bordered plaques. The edema may suggest vesicles, but on palpation the lesions are solid, and vesicles. | Chapter 082. Infections in Patients with Cancer Part 5 Sweet s syndrome or febrile neutrophilic dermatosis was originally described in women with elevated white blood cell WBC counts. The disease is characterized by the presence of leukocytes in the lower dermis with edema of the papillary body. Ironically this disease now is usually seen in neutropenic patients with cancer most often in association with acute leukemia but also in association with a variety of other malignancies. Sweet s syndrome usually presents as red or bluish-red papules or nodules that may coalesce and form sharply bordered plaques. The edema may suggest vesicles but on palpation the lesions are solid and vesicles probably never arise in this disease. The lesions are most common on the face neck and arms. On the legs they may be confused with erythema nodosum. The development of lesions is often accompanied by high fevers and an elevated erythrocyte sedimentation rate. Both the lesions and the temperature elevation respond dramatically to glucocorticoid administration. Treatment begins with high doses of glucocorticoids 60 mg d of prednisone followed by tapered doses over the next 2-3 weeks. Data indicate that erythema multiforme with mucous membrane involvement is often associated with herpes simplex virus HSV infection and is distinct from Stevens-Johnson syndrome which is associated with drugs and tends to have a more widespread distribution. Since cancer patients are both immunosuppressed and therefore susceptible to herpes infections and heavily treated with drugs and therefore subject to Stevens-Johnson syndrome both of these conditions are common in this population. Cytokines which are used as adjuvants or primary treatments for cancer can themselves cause characteristic rashes further complicating the differential diagnosis. This phenomenon is a particular problem in bone marrow transplant recipients Chap. 126 who in addition to having the usual chemotherapy- antibiotic- and .

• Y học thường thức
• Infections in Patients with Cancer
• bệnh học và điều trị
• bài giảng bệnh học
• tài liệu y khoa
• Harrisons Internal Medicine
• Nosocomial infection
• Intensive care unit
• Regional cancer center
• Nosocomial infections
• Molecular diagnosis of bacterial resistance
• Patients admitted
• Oncology Patients
• Cancer Illness
• Pediatric Infectious
• Fungal Infections
• Patients of Paediatric Age
• Infantile Chronic
• Mycobacterium tuberculosis direct test
• Mycobacteria growth indicator tube
• TB infections
• Cancer patients
• Conventional diagnostic methods