TAILIEUCHUNG - Báo cáo y học: "The increase of plasma galectin-9 in a patient with insulin allergy: a case report"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The increase of plasma galectin-9 in a patient with insulin allergy: a case report. | Chagan-Yasutan et al. Clinical and Molecular Allergy 2010 8 12 http content 8 1 12 CMA CLINICAL AND MOLECULAR ALLERGY CASE REPORT Open Access The increase of plasma galectin-9 in a patient with insulin allergy a case report 11 111 Haorile Chagan-Yasutan Beata Shiratori Umme Ruman Siddiqi Hiroki Saitoh Yugo Ashino Tomohiro Arikawa2 Mitsuomi Hirashima2 Toshio Hattori1 Abstract Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 GAL-9 and osteopontin OPN . Here we examined plasma levels of GAL-9 and OPN first time in a case of 65-year old patient with insulin allergy. Insulin aspart insulin aspart 30 mix were given to the patient and an elevation of the eosinophil count 8440 gl fold and a moderate increase of IgE 501 U ml reference range 10-350 U ml eotaxin-3 168 pg ml 2 fold histamine ng ml fold were found 33 days later. The plasma levels of GAL-9 and OPN were and fold higher than the cut-off point respectively. After one month cessation of insulin therapy elevations of the eosinophil count 3 480 gl fold and OPN fold still occurred but the GAL-9 levels became normal. Therefore we noted the increases of GAL-9 and OPN in plasma for the first time in a patient with insulin allergy and propose that GAL-9 reflects the conditions of allergy more accurately. Background Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE 1 . We studied novel pro-inflammatory molecules such as galectin-9 GAL-9 and osteopontin OPN in a patient with insulin allergy because the involvement of these molecules in eosinophilia has been recently proposed 2 3 . OPN is a glycoprotein believed to be involved in Th1 inflammation in various infectious diseases including HIV as we described previously 4 . Recently it was reported that OPN is synthesized by eosinophils and was .

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