TAILIEUCHUNG - Chapter 039. Nausea, Vomiting, and Indigestion (Part 9)

Helicobacter pylori Eradication H. pylori eradication is clearly indicated only for peptic ulcer and mucosaassociated lymphoid tissue gastric lymphoma. The utility of eradication therapy in functional dyspepsia is less well established | Chapter 039. Nausea Vomiting and Indigestion Part 9 Helicobacter pylori Eradication H. pylori eradication is clearly indicated only for peptic ulcer and mucosa-associated lymphoid tissue gastric lymphoma. The utility of eradication therapy in functional dyspepsia is less well established but 15 of cases relate to this infection. Meta-analysis of 13 controlled trials calculated a risk ratio of with a 95 confidence interval of favoring H. pylori eradication therapy over placebo. Several drug combinations show efficacy in eliminating the infection Chap. 287 most include 10-14 days of a proton pump inhibitor or bismuth subsalicylate in concert with two antibiotics. H. pylori infection is associated with reduced prevalence of GERD especially in the elderly. However eradication of the infection does not worsen GERD symptoms. To date no consensus recommendations regarding H. pylori eradication in GERD patients have been offered. Gastrointestinal Motor Stimulants Motor stimulants also known as prokinetics such as metoclopramide erythromycin domperidone and tegaserod have limited utility in GERD. The y-aminobutyric acid B GABA-B agonist baclofen reduces esophageal acid exposure by inhibiting transient LES relaxations the clinical benefits of this drug are yet to be defined in large trials. Several studies have evaluated the effectiveness of motor-stimulating drugs in functional dyspepsia however convincing evidence of their benefits has not been found. Some clinicians suggest that patients with symptoms resembling postprandial distress may respond preferentially to prokinetic drugs. Other Options Antireflux surgery fundoplication is offered to GERD patients who are young and may require lifelong therapy have typical heartburn and regurgitation and are responsive to proton pump inhibitors. Individuals who may respond less well to operative therapy include those with atypical symptoms those with poor response to proton pump inhibitors and those who have .

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