TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 165

Pharmaceutical Substances Syntheses, Patents, Applications - Part 165. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Pinazepam P 1641 Pinazepam atc nosbau Use tranquilizer RN 52463-83-9 MF C18H13C1N2O MW EINECS 257-934-9 LD50 1302 mg kg M . 5819 mg kg R . CN 7-chloro-1 3-dihydro-5-phenyl-1 - 2-propynyl -2 -1 4-benzodiazepin-2-one 7-chloro-1 3-dihydro- 2-propynyl 5-phenyl-2H-1 4-benzo- bromide diazepin-2-ane cf. diazepam synthesis NoOCHj. CHjOH Reference s . DOS 2 339 790 Zambeletti appl. I-prior. . GB 1 406 946 Zambeletti valid from I-prior. . alternative synthesis US 3 842 094 Delmar Chem. prior. . Formulation s cps. mg 5 mg 10 mg Trade Name s 1 Domar Teofarma Pindolol ATC C07AA03 . Use beta blocking agent RN 13523-86-9 MF Cl4H20N2O2 MW EINECS 236-867-9 LD5o mg kg M . 235 mg kg M . 51 mg kg R . 263 mg kg R . CN l- l -indol-4-yloxy -3- l-mcthylethyl amino -2-propanol 3-chloro-1 - 4- ndolyloxy -2-propanol 4-hydroxy- epichloro- indole hydrin 1642 P Pioglitazone Reference s DE I 620 342 Sandoz prior. . US 3 471 515 Sandoz CH-prior. . CH 453 363 Sandoz appl. . Formulation s amp. mg 2 ml eye drops 5 mg ml 10 mg 5 ml s. r. tabl. 20 mg tabl. mg 5 mg 10 mg 15 mg Trade Name s D Durapindol durachemie Visken Novartis Pharma I Visken Novartis Farma Glauco-Stulln Pharma 1971 1973 Stulln F Viskaldix Novartis -comb. J Carviskcn Sankyo Pindoptan Kanoldt Visken Novartis 1971 USA Visken Sandoz 1982 Viskaldix Novartis GB Viskaldix Novartis -comb. wfm Pharma -comb. Visken Novartis 1974 generics Pioglitazone atc aiobgo3 AD-4833 U 72107 se antidiabetic insulinenhancer RN 111025-46-8 MF C19H20N2O3S MW CN -5- 4- 2- 5-Ethyl-2-pyridinyl ethoxy phenyl methyl -2 4-thiazolidinedione hydrochloride RN 112529-15-4 MF C19H20N2O3S HC1 MW 2- 5-ethyl-2- 4-fluoro-1 - pyridyl ethonal I nitrobenzene 4- 2- 5-ethyl-2-pyridyl ethoxy -1-nitrobenzene II II H2. Pd-C CH30H 1. NqN02 HBr Cu2O. H20 0 2. --------------------------- 2. methyl acrylate Ill methyl 2-bromo-3-

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