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Pharmaceutical Substances Syntheses, Patents, Applications - Part 165. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Pinazepam P 1641 Pinazepam atc nosbau Use tranquilizer RN 52463-83-9 MF C18H13C1N2O MW 308.77 EINECS 257-934-9 LD50 1302 mg kg M p.o. 5819 mg kg R p.o. CN 7-chloro-1 3-dihydro-5-phenyl-1 - 2-propynyl -2 -1 4-benzodiazepin-2-one 7-chloro-1 3-dihydro- 2-propynyl 5-phenyl-2H-1 4-benzo- bromide diazepin-2-ane cf. diazepam synthesis NoOCHj. CHjOH Reference s . DOS 2 339 790 Zambeletti appl. 6.8.1973 I-prior. 9.8.1972 . GB 1 406 946 Zambeletti valid from 28.6.1973 I-prior. 9.8.1972 . alternative synthesis US 3 842 094 Delmar Chem. 15.10.1974 prior. 31.8.1972 . Formulation s cps. 2.5 mg 5 mg 10 mg Trade Name s 1 Domar Teofarma Pindolol ATC C07AA03 . Use beta blocking agent RN 13523-86-9 MF Cl4H20N2O2 MW 248.33 EINECS 236-867-9 LD5o 22.6 mg kg M i.v. 235 mg kg M p.o. 51 mg kg R i.v. 263 mg kg R p.o. CN l- l -indol-4-yloxy -3- l-mcthylethyl amino -2-propanol 3-chloro-1 - 4- ndolyloxy -2-propanol 4-hydroxy- epichloro- indole hydrin 1642 P Pioglitazone Reference s DE I 620 342 Sandoz prior. 26.1.1966 . US 3 471 515 Sandoz 7.10.1967 CH-prior. 1.2.1965 . CH 453 363 Sandoz appl. 1.2.1965 . Formulation s amp. 0.4 mg 2 ml eye drops 5 mg ml 10 mg 5 ml s. r. tabl. 20 mg tabl. 2.5 mg 5 mg 10 mg 15 mg Trade Name s D Durapindol durachemie Visken Novartis Pharma I Visken Novartis Farma Glauco-Stulln Pharma 1971 1973 Stulln F Viskaldix Novartis -comb. J Carviskcn Sankyo Pindoptan Kanoldt Visken Novartis 1971 USA Visken Sandoz 1982 Viskaldix Novartis GB Viskaldix Novartis -comb. wfm Pharma -comb. Visken Novartis 1974 generics Pioglitazone atc aiobgo3 AD-4833 U 72107 se antidiabetic insulinenhancer RN 111025-46-8 MF C19H20N2O3S MW 356.45 CN -5- 4- 2- 5-Ethyl-2-pyridinyl ethoxy phenyl methyl -2 4-thiazolidinedione hydrochloride RN 112529-15-4 MF C19H20N2O3S HC1 MW 392.91 2- 5-ethyl-2- 4-fluoro-1 - pyridyl ethonal I nitrobenzene 4- 2- 5-ethyl-2-pyridyl ethoxy -1-nitrobenzene II II H2. Pd-C CH30H 1. NqN02 HBr Cu2O. H20 0 2. --------------------------- 2. methyl acrylate Ill methyl 2-bromo-3-
