TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 190

Pharmaceutical Substances Syntheses, Patents, Applications - Part 190. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | spiperone s 1891 Formulation s vial 3 g as dihydrochloride pentahydrate Trade Name s D Stanilo Pharmacia Upjohn F Trobicine Pharmacia Upjohn GB Trobicin Pharmacia Upjohn 1 Trobicin Pharmacia Upjohn J Trobicin Nihon Upjohn USA Trobicin Upjohn wfm Spiperone ATC N05C Use neuroleptic RN 749-02-0 MF C23H26FN3O2 MW E1NECS 212-024-0 LD50 mg kg M . 600 mg kg M . 14 mg kg R . 1 g kg R . 20 mg kg dog . 100 mg kg dog p 0. CN 8- 4- 4-fluorophenyl -4-oxobutyl -l-phenyl-l 3 8-triazaspiro decan-4-one 4-chloro-4 -fluoro- butyrophenone cf. holoperidol synthesis 4-axo-1-phenyl-1 3 8-tñazaspíro- decane cf. fluspirilene synthesis Reference s US 3 155 669 Janssen appl. . US 3 155 670 Janssen appl. . US 3 161 644 Janssen appl. . Formulation s tabl. mg vial 3 mg Trade Name s J spiropitan Eisai Spiramycin ATC J01FA02 Use antibiotic RN 8025-81-8 MF unspecified MW unspecified EINECS 232-429-6 LD50 130mg kg M . 2900 mg kg M . 170mg kg R . 3550 mg kg R . 5200 mg kg dog . CN spiramycin 1892 S Spirapril Spiramycin 1 Spiramycin 11 Spiramycin Ill From culture of Streptomyces ambofaciens. Reference s US 2 943 023 Rhöne-Poulenc F-prior. . US 2 978 380 Rhöne-Poulenc F-prior. . US 3 000 785 Rhöne-Poulenc F-prior. . US 3 011 947 Rhöne-Poulenc F-prior. . Pinnert-Sindico S. et al. Antibiot. Annu. ABANAE 1954-1955 724. Formulation s f. c. tabl. mg 250 mg 375 mg 500 mg Trade Name s D Rovamycine Rhöne- Poulenc Rorer Selectomycin Grünenthal F Rodogyl Specia -comb. Rovamycine Specia GB Rovamycin May Baker wfm I Rovamicina Rhöne- Poulenc Rorer Spirapril Sch-33844 ATC C09AA11 Use antihypertensive ACE inhibitor RN 83647-97-6 MF C22H30N2O5S2 MW LD5 2500 mg kg M . 2500 mg kg R . CN 8S- 7 R R 8R -7- 2- l- ethoxycarbonyl -3-phenylpropyl amino -l-oxopropyl -l 4-dithia-7-azaspiro nonane-8-carboxylic .

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