TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 206

Pharmaceutical Substances Syntheses, Patents, Applications - Part 206. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers. | Tiopronin T 2051 Trade Name s D Emdabol Merck wfm Gerantabol Merck -comb. wfm Tiopronin Mercamidum ATC R05CB12 Use detoxicant liver therapeutic hepatoprotectant mucolytic RN 1953-02-2 MF C5H9NO3S MW EINECS 217-778-4 LD50 1733 mg kg M . 2330 mg kg M . 1300 mg kg R . CN lV- 2-mercapto-1 -oxopropy l glycine monosodium salt RN 2015-25-0 MF C5H8NNaO3S MW LD q 2100 mg kg M . H cA Br H2N COOH 3 0 NaHCOj ------- r H n 0 NaSH ---- 2-bromo- glycine propionyl bromide N- 2-bromopropionyl -glycine SH H H cA-N C00H 3 0 Tiopronin Reference s FR 1 491 204 Santen appl. J-prior. . FR-M 3 081 Santen appl. J-prior. . GB 1 023 003 Santen appl. . use as mucolytic agent GB 1 482 651 Lab. Cassenne appl. USA-prior. . US 3 857 951 Lab. Cassenne appl. . against nosotoxicosa US 3 897 480 Santen J-prior. . sodium salt DOS 2 924 231 P. Gargani appl. I-prior. . Formulation s amp. 100 mg 250 mg drg. 100 mg 250 mg gran. 150 mg 350 mg tabl. 100 mg Trade Name s D Captimer Fresenius Thiola Coop. Farm. USA Thiola Mission F Acadione Cassenne Thiosol Coop. Farm. 1 Mucolysin Farmila J Thiola Santen Tiotixene atc nosafo4 Thiothixene Use neurolePtic RN 3313-26-6 MF C23H29N3O2S2 MW LD50 100 mg kg M . 55 mg kg R . CN Z -7V V-dimethyl-9- 3- 4-methyl-l-piperazinyl propylidene -9 -thioxanthene-2-sulfonamide 2052 T Tiotixene dihydrochloride dihydrate RN 22189-31-7 MF C23H29N3O2S2 2HC1 2H2O MW ci-sd3h acid chlorosulfonic 9H-thioxonthene-2- sulfonic acid 2-dimethylaminosulfonyl- 9H-thioxanthene n 2. UN. ch3 1. thionyl chloride 2. dimethylamine 1 2. methyl acetate 9-acetyl-2-dimethylamina- III sulfonyl-9H-thioxanthene ch3 III 1 -methylpiperazine IV POCI3 ------------ phosphoryl chloride Reference s US 3 310 553 Pfizer appl. prior. . DE 1 470 157 Pfizer appl. USA-prior. .

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