TAILIEUCHUNG - Pharmaceutical Substances Syntheses, Patents, Applications - Part 2

Pharmaceutical Substances Syntheses, Patents, Applications - Part 2. Reference containing a collection of 2267 active pharmaceutical ingredients, including those launched recently. Listed alphabetically according to their INNs and established a link between INNs, structure, synthesis and production processes, patent and literature situation, medical use, and trade names. For pharmacists and researchers | Aceglutamide aluminum A 11 Aceglutamide aluminum ATC A02AB N06B Use peptic ulcer therapeutic RN 12607-92-0 MF Cjs AIjN Om MW LD50 460 mg kg M . g kg M . 400 mg kg R . g kg R . CN pentakisfA1 2 - acctyll -glutaminato tctrahydroxy trialuminum 0 0 1 2 h3cAoAch3 Y cooh acetic anhydride L-glutamine n __HN CH3 H2NY A C00H 0 KI -acetyl-L-glutamine 1 AI 0CH CH3 2 3 ----- aluminum isopropylate HN j. HzN A o- ai3 oh 4 5 0 0 . 5 Aceglutamide aluminum Reference s DOS 2 127 176 Kyowa Hakko appl. J-prior. . US 3 787 466 Kyowa Hakko J-prior. . preparation 0 Reddy Ravindranath B. Synth. Commun. SYNCAV 22 2 257 1992 . Synge Biochem. J. BIJOAK 33 673 1939 . Formulation s gran. 700 mg Trade Name s J Glumal Kyowa Hakko Acemetacin atc-. moiabu Use non-stcroidal anti-inflammatory RN 53164-05-9 MF C21HI8C1NO6 MW EINECS 258-403-4 LD5o 55 mg kg Mm . kg Mf . mg kg Rm . mg kg Rf . CN l- 4-chlorobenzoyl -5-methoxy-2-methyl-l -indole-3-acetic acid carboxymethyl ester 4-methoxyaniline 1. NaN02 H 2. No2SO3 or SnCI2 HCI 4-methoxyphenyihydrazine 1 i 12 A Acemetacin 1. NaOC2H5 2. ci n 0 i3c_ cooh 0 0 3 ------------ ii 2. benzyl chloroacetate Q Q levulinic acid benzyl levulinoyloxyacetate H3C benzyl 2- 4-methoxyphenylhydrazono -valeryloxy ocetate n acetaxy acetate ID III NaH DMF ---------- 0 4-chloro- benzoyl chloride benzyl 1 - 4-chlorobenzoyl -5-methoxy- 2-methyl-3-indolylocetoxy acetate IV H2 Pd-C CH3COOH IV ----------------- IV H2 Pd-C CH3COOH Acemetacin indometacin q- v- benzyl bromoacetate Reference s DOS 2 234 651 Tropon appl. . FR 2 192 828 Tropon appl. D-prior. . US 3 910 952 Troponwerke Dinklage appl. D-prior. . Acenocoumarol A 13 preparation o 4-methoxyphenylhydrazine from 4-methoxyaniline p-anisidine Lee . et al. J. Heterocycl. Chem. JHTCAD 32 1 1-12 1995 . Clade . et al. J. Chem.

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