TAILIEUCHUNG - Percent change in apparent difusion coefcient and plasma EBV DNA after induction chemotherapy identifies distinct prognostic response phenotypes in advanced nasopharyngeal carcinoma

To evaluate the prognostic value of the apparent diffusion coefficient (ADC) derived from difusionweighted magnetic resonance imaging (MRI) and monitor the early treatment response to induction chemotherapy (IC) with plasma EBV DNA in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). | Liu et al. BMC Cancer 2021 21 1320 https s12885-021-09063-1 RESEARCH Open Access Percent change in apparent diffusion coefficient and plasma EBV DNA after induction chemotherapy identifies distinct prognostic response phenotypes in advanced nasopharyngeal carcinoma Li Ting Liu1 2 Shan Shan Guo1 2 Hui Li1 3 Chao Lin1 2 Rui Sun1 2 Qiu Yan Chen1 2 Yu Jing Liang1 2 Qing Nan Tang1 2 Xue Song Sun1 2 Lin Quan Tang1 2 Chuan Miao Xie1 3 and Hai Qiang Mai1 2 Abstract Background To evaluate the prognostic value of the apparent diffusion coefficient ADC derived from diffusion- weighted magnetic resonance imaging MRI and monitor the early treatment response to induction chemotherapy IC with plasma EBV DNA in locoregionally advanced nasopharyngeal carcinoma LA-NPC . Results A total of 307 stage III-IVb NPC patients were prospectively enrolled. All patients underwent MRI examina tions to calculate ADC and plasma EBV DNA measurements pretreatment and post-IC. The participants ADC value of 284 307 increased post-IC. A higher percent change in ADC value ΔADC high group post-IC was associated with a higher 5-year OS rate vs p Liu et al. BMC Cancer 2021 21 1320 Page 2 of 9 advanced NPC LA-NPC the curative effects of induc- November 2016 we recruited 386 biopsy-confirmed tion chemotherapy IC followed by concurrent chemo- newly diagnosed NPC patients. Inclusion criteria are therapy CCRT have been investigated for the past listed as follows 1 age 18 years old 2 stage III-IVb decade 4 6 . An increasing number of clinical trials disease according to the seventh edition of the Interna- have shown that IC is a relatively safe and effective treat- tional Union Against Cancer American Joint Commit- ment method for LA-NPC that significantly improves tee on Cancer staging system 3 score of 0 or 1 on the clinical outcomes 7 8 . Benefiting from the development Eastern Cooperative Oncology Group ECOG perfor- of radiation techniques and multimodality therapies the .

• Y khoa - Dược
• BMC Cancer
• Nasopharyngeal carcinoma
• Apparent difusion coefficient
• Response phenotypes
• Intensity modulated radiotherapy
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study