TAILIEUCHUNG - Use of the biopharmaceutics drug disposition classification system (BDDCS) to help predict the occurrence of idiosyncratic cutaneous adverse drug reactions associated with antiepileptic drug usage

Cutaneous adverse reactions (CARs) from antiepileptic drugs (AEDs) are common, ranging from mild to life-threatening, including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The identification of subjects carrying the HLA-B*15:02, an inherited allelic variant of the HLAB gene, and the avoidance of carbamazepine (CBZ) therapy in these subjects are strongly associated with a decrease in the incidence of carbamazepine-induced SJS/TEN. In spite of the strong genetic associations, the initiation of hypersensitivity for AEDs is still not very well characterized. Predicting the potential for other AEDs to cause adverse reactions will be undoubtedly beneficial to avoid CARs, which is the focus of this report. Here, we explore the use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to distinguish AEDs associated with and without CARs by examining the binding relationship of AEDs to HLA-B*15:02 and data from extensive reviews of medical records. We also evaluate the lack of benefit from a Hong Kong population policy on the effects of screening for HLA-B*15:02 and previous incorrect structure–activity hypotheses. | Use of the biopharmaceutics drug disposition classification system BDDCS to help predict the occurrence of idiosyncratic cutaneous adverse drug reactions associated with antiepileptic drug usage

• Y khoa - Dược
• Antiepileptic drugs
• Drug hypersensitivity
• HLA B alleles
• Biopharmaceutics drug disposition classification system
• HLAB gene
• Behavioural neurology
• Comparative evidence
• Clinical scenarios
• Phenobarbital and primidone
• Behavioural co morbidities
• Clonazepam and clobazam
• BMC Pediatrics
• Valproic acid
• Skeletal system determines
• Statural growth
• BMC Pharmacology and Toxicology
• Adverse drug reactions
• Antiepileptic drug
• Severe adverse reactions
• Psychiatric ADRs
• Voltage gated sodium channels
• Drug targets
• Adjusted sequence ratio
• Information component
• Medical pharmacology at a glance
• Lipid lowering drugs
• General anaesthetics
• Agents used in anaemias
• Anxiolytics and hypnotics
• Antipsychotic drugs
• Growth velocity
• Bone metabolism
• Tartrate resistant acid phosphatase 5b
• Bonespecific alkaline phosphatase
• Systematic review
• Cost effective
• Pharmacoeconomic evaluations
• Chronic non communicable disease
• Autism spectrum disorder
• Non traditional treatments
• Abnormal electroencephalograms