TAILIEUCHUNG - Ebook Medical pharmacology at a glance (7th edition): Part 2

(BQ) Part 2 book "Medical pharmacology at a glance" presents the following contents: Lipid-lowering drugs, general anaesthetics, agents used in anaemias, anxiolytics and hypnotics, antiepileptic drugs, antipsychotic drugs, opioid analgesics, drugs used in nausea and vertigo, antidiabetic agents,. and other contents. | 20 Lipid-lowering drugs Endocytosis HMG CoA inhibitors Lysis Anionic exchange resins CE colestyramine colestipol LDL atorvastatin simvastatin pravastatin others Cholesterol LDL-R nicotinic acid Increase A Fibrates Inhibit A VLDL BA Bile duct A BA BA HMG CoA HMG CoA reductase mevalonate – CE Cholesterol + TG Portal vein BA TG HDL A BA LDL receptor bezafibrate fenofibrate others Activate Lipoprotein lipase (in muscle and adipose tissue capillaries) chol CE A BA Bile acid excretion INHIBITOR of cholesterol absorption ezetimibe Lipids, such as triglycerides and cholesterylesters, are insoluble in water and are transported in plasma in the core of particles (lipoproteins) that have a hydrophilic shell of phospholipids and free cholesterol. This surface layer is stabilized by one or more apolipoproteins, which also act as ligands for cell surface receptors. About two-thirds of plasma lipoproteins are synthesized in the liver (middle, shaded (yellow)). Triglycerides (TG) are secreted into the blood as very-low). In muscle and adipose tissue, the density lipoproteins (VLDL, capillaries (right) possess an enzyme, lipoprotein lipase ( ), that hydrolyses the triglycerides to fatty acids; these then enter the muscle cells (for energy) and adipocytes (for storage). The residual particles containing a core rich in cholesterylester (CE) are called low-density lipoprotein (LDL) particles. The liver and other cells possess LDL ) that remove LDL from the plasma by endocytosis receptors ( (top figure shaded orange). The hepatic receptor-mediated removal of LDL is the main mechanism for controlling plasma LDL levels. Fatty acids and cholesterol from ingested dietary fat are re-esterified in mucosal cells of the intestine and form the core of chylomicrons, which enter the plasma via the thoracic duct. Fatty acids are Fatty acids LDL hydrolysed from the chylomicrons by lipoprotein lipase, and the residual triglyceride-depleted remnants are removed by .

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• Medical pharmacology at a glance
• Lipid lowering drugs
• General anaesthetics
• Agents used in anaemias
• Anxiolytics and hypnotics
• Antiepileptic drugs
• Antipsychotic drugs
• Drug absorption
• Drug metabolism
• Local anaesthetics
• Autonomic nervous system
• Drugs acting on the sympathetic system
• Ocular pharmacology
• Endovascular surgery
• Arterial anatomy
• Venous anatomy
• Vascular biology
• Vascular pathobiology
• Vascular pharmacology
• Cardiovascular risk factors
• Best medical therapy
• Vascular history taking
• Drug Elimination
• Antipsychotics
• Extrapyramidal Symptoms
• Drug Administration
• Pharmacological Management
• BMC Pharmacology and Toxicology
• Antipsychotic prescribing
• Inappropriate prescribing
• Psychological Symptoms of Dementia
• Adolescent psychiatry
• Mental health
• Second generation antipsychotics
• Cross sectional design
• Psychiatric Drugs
• Treat Anxiety
• Antipsychotic Medications
• Sleeping Disorders
• Somatization Disorder
• Mood Swings
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• tài liệu báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu y học
• kiến thức y học
• báo cáo khoa học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Nuclear protein
• Rat prefrontal cortex
• Neuronal cell
• Glial cell
• Serious adverse events
• Data mining
• Second generation antipsychotic drugs
• Food and Drug Administration
• Adverse Event Reporting System