TAILIEUCHUNG - Synthesis and bioacivity screening of some novel N-(Adamantan-1-yl)-1-Aryl-Methanimines

Synthesis and bioactivity testing of some novel N-(adamantan-1-yl)-1-arylmethanimines derivatives. Methods: The novel of N-(adamantan-1-yl)-1-aryl-methanimines were synthesized by the condensation of 1-aminoadamantane with aromatic aldehydes in absolute ethanol under the catalyzation of acetic acid. Synthesized compounds were bioactivity tested as inhibition of acetylcholinesterase, antimicrobial, anticancer in vitro. Results: A new series of N- (adamantan-1-yl)-1- aryl-methanimines was designed, synthesized and evaluated for their inhibition of acetylcholinesterase, antimicrobial, anticancer. Representative two compounds did not show the inhibition of acetylcholinesterase and antimicrobials (S. aureus, B. subtilis, L. fermentum, S. enterica, E. coli, P. aureus). However, synthesize compounds were shown to be promising in at least three tumor cell lines with IC50 from - µg/mL. Otherwise, five per ten compounds possessed the activity against C. albican. Conclusions: At the present work, it had synthesized ten novel N-(adamantan-1-yl)-1-aryl-methanimine derivatives, between them, some compounds were identified against C. albican and with significant cytotoxic activity in testing tumor cell lines. | Synthesis and bioacivity screening of some novel N-(Adamantan-1-yl)-1-Aryl-Methanimines

• Y khoa - Dược
• Synthesis and bioacivity screening
• N (Adamantan 1 yl) 1 Aryl Methanimines
• Synthesis and bioactivity testing
• aromatic aldehydes
• Inhibition of acetylcholinesterase
• Arnica montana
• Antioxidant activity
• Acetylcholinesterase inhibition
• Phenolic compounds
• Ferric reducing antioxidant power
• Arnebia densiflora
• Thin layer chromatography
• Alzheimer’s disease
• Journal of Chemistry
• Butyrylcholinesterase inhibition
• Benzobicyclo[3 2 1]octenes
• Benzobicyclo[3 2 1]octadienes
• Alzheimer’s disease
• Scientific reports
• scientific research
• biochemistry
• genetics
• Structural biochemistry
• Structural Biology
• Report medicine
• traditional medicine
• medical research
• hemoglobin
• medical knowledge
• Carbonic anhydrase
• Enzyme inhibition
• Benzamide pharmacophores
• Neurotransmitter acetylcholine
• Mannich bases
• Molecular docking
• Alzheimer’s disease (AD)
• Carbonic anhydrases (CAs)
• Spectroscopic characterizations