TAILIEUCHUNG - Biochemistry and essentials factors (Second edition): Part 2

(BQ) Continued part 1, part 2 of the document Biochemistry and essentials factors (Second edition) has contents: Water metabolism, mineral metabolism, hemoglobin metabolism, purine and pyrimidine nucleotide metabolism, replication, transcription and translation, genetic engineering, mechanism of hormone action,. and other contents. Invite you to refer. | CHAPTER 16 ___________ Water Metabolism Chapter outline Importance of Water Total Body Water TBW and its Distribution Normal Water Balance Electrolytes Regulation of Water and Electrolyte Balance Disorders of Water and Electrolyte Balances INTRODUCTION Water is the most abundant constituent of the human body accounting approximately 60 to 70 of the body mass in a normal adult. Water content of the body changes with age. It is about 75 in the newborn and decreases to less than 50 in older individuals. Water content is greatest in brain tissue and least in adipose tissue. IMPORTANCE OF WATER It is a medium in which body solutes both organic and inorganic are dissolved and metabolic reactions take place. It acts as a vehicle for transport of solutes. Water itself participates as a substrate and a product in many chemical reactions . in glycolysis citric acid cycle and respiratory chain. The stability of subcellular structures and activities of numerous enzymes are dependent on adequate cell hydration. Water is involved in the regulation of body temperature because of its highest latent heat of evaporation. Water also acts as a lubricant in the body so as to prevent friction in joints pleura peritoneum and conjunctiva. Both a relative deficiency and an excess of water impair the function of tissues and organs. TOTAL BODY WATER TBW AND ITS DISTRIBUTION Total body water includes water both inside and outside of cells and water normally present in the gastrointestinal and genitourinary systems. Total body water Fig. Body water compartments Total body water can be theoretically divided into two main compartments Fig. 1. Extracellular water ECW and 2. Intracellular water ICW . The ECW includes all water external to cell membranes. The ECW can be further subdivided into - Intravascular water . plasma - Extravascular water . interstitial fluid. The ICW includes all water within cell membranes and constitutes the medium in which chemical reactions of cell .

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