TAILIEUCHUNG - Báo cáo khoa học: Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase

Spontaneous oxidation of 3-hydroxykynureine (3-HK), a metabolic inter-mediate of the tryptophan degradation pathway, elicits a remarkable oxida-tive stress response in animal tissues. In the yellow fever mosquito Aedes aegyptithe excess of this toxic metabolic intermediate is efficiently removed by a specific 3-HK transaminase, which converts 3-HK into the more sta-ble compound xanthurenic acid. | ềFEBS Journal Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase Franna RhccÍ1 PahrĨTĨn I nmhardH2 Ạ Inooonrlro Pan 11 nn1 a nĩ 11 a f aeea ni1 a n 11 ma IK linlin1 rial iua nuddi f rauiizio LUI 1iuai uo f I eooai I Vila I ay III io f vai 11111a vassal II fVjiaiiiucaiviiyiio f Bruno Area2 3 and Menico Rizzi1 1 DiSCAFF University of Piemonte Orientale Amedeo Avogadro Novara Italy 2 Dipartimento di Scienze di Sanita Pubblica - Sezione di Parassitologia Universita di Roma La Sapienza Italy 3 Dipartimento di Biologia Strutturale e Funzionale University di Napoli Federico II Italy Keywords Anopheles gambiae 3-hydroxykynurenine transaminase xanthurenic acid Plasmodium gametogenesis PLP dependent enzyme Correspondence M. Rizzi DiSCAFF University of Piemonte Orientale Amedeo Avogadro Via Bovio 6 28100 Novara Italy Fax 39 0321375821 Tel 39 0321375812 E-mail Received 26 July 2005 revised 31 August 2005 accepted 6 September 2005 doi Spontaneous oxidation of 3-hydroxykynureine 3-HK a metabolic intermediate of the tryptophan degradation pathway elicits a remarkable oxidative stress response in animal tissues. In the yellow fever mosquito Aedes aegypti the excess of this toxic metabolic intermediate is efficiently removed by a specific 3-HK transaminase which converts 3-HK into the more stable compound xanthurenic acid. In anopheline mosquitoes transmitting malaria xanthurenic acid plays an important role in Plasmodium gametocyte maturation and fertility. Using the sequence information provided by the Anopheles gambiae genome and available ESTs we adopted a PCR-based approach to isolate a 3-HK transaminase coding sequence from the main human malaria vector A. gambiae. Tissue and developmental expression analysis revealed an almost ubiquitary profile which is in agreement with the physiological role of the enzyme in mosquito development and 3-HK detoxification. A .

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